joaquin
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I found this today. Not sure if Neurosciencenews.com is reputable as many websites are funded by Pharm. But the article here is interesting. It has to do with the calf muscle and how it can help burn glucose and fat. Link to article
neurosciencenews.com
6 min
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Summary: The pioneering “soleus pushup” effectively elevates muscle metabolism for hours, even when sitting.
Source: University of Houston
From the same mind whose research propelled the notion that “sitting too much is not the same as exercising too little,” comes a groundbreaking discovery set to turn a sedentary lifestyle on its ear: The soleus muscle in the calf, though only 1% of your body weight, can do big things to improve the metabolic health in the rest of your body if activated correctly.
And Marc Hamilton, professor of Health and Human Performance at the University of Houston, has discovered such an approach for optimal activation – he’s pioneering the “soleus pushup” (SPU) which effectively elevates muscle metabolism for hours, even while sitting. The soleus, one of 600 muscles in the human body, is a posterior leg muscle that runs from just below the knee to the heel.
Published in the journal iScience, Hamilton’s research suggests the soleus pushup’s ability to sustain an elevated oxidative metabolism to improve the regulation of blood glucose is more effective than any popular methods currently touted as a solution including exercise, weight loss and intermittent fasting. Oxidative metabolism is the process by which oxygen is used to burn metabolites like blood glucose or fats, but it depends, in part, on the immediate energy needs of the muscle when it’s working.
“We never dreamed that this muscle has this type of capacity. It’s been inside our bodies all along, but no one ever investigated how to use it to optimize our health, until now,” said Hamilton. “When activated correctly, the soleus muscle can raise local oxidative metabolism to high levels for hours, not just minutes, and does so by using a different fuel mixture.”
Muscle biopsies revealed there was minimal glycogen contribution to fueling the soleus. Instead of breaking down glycogen, the soleus can use other types of fuels such as blood glucose and fats. Glycogen is normally the predominant type of carbohydrate that fuels muscular exercise.
“The soleus’ lower-than-normal reliance on glycogen helps it work for hours effortlessly without fatiguing during this type of muscle activity, because there is a definite limit to muscular endurance caused by glycogen depletion,” he added. “As far as we know, this is the first concerted effort to develop a specialized type of contractile activity centered around optimizing human metabolic processes.”
When the SPU was tested, the whole-body effects on blood chemistry included a 52% improvement in the excursion of blood glucose (sugar) and 60% less insulin requirement over three hours after ingesting a glucose drink.
The new approach of keeping the soleus muscle metabolism humming is also effective at doubling the normal rate of fat metabolism in the fasting period between meals, reducing the levels of fat in the blood (VLDL triglyceride).
The Soleus Pushup
Building on years of research, Hamilton and his colleagues developed the soleus pushup, which activates the soleus muscle differently than when standing or walking. The SPU targets the soleus to increase oxygen consumption – more than what’s possible with these other types of soleus activities, while also being resistant to fatigue.
Marc Hamilton, professor of Health and Human Performance at the University of Houston, is pioneering the “soleus pushup” for the calf muscle that is only 1% of your body weight, but can improve the metabolic health in the rest of your body if activated correctly. Credit: University of Houston
So, how do you perform a soleus pushup?
In brief, while seated with feet flat on the floor and muscles relaxed, the heel rises while the front of the foot stays put. When the heel gets to the top of its range of motion, the foot is passively released to come back down. The aim is to simultaneously shorten the calf muscle while the soleus is naturally activated by its motor neurons.
While the SPU movement might look like walking (though it is performed while seated) it is the exact opposite, according to the researchers. When walking, the body is designed to minimize the amount of energy used, because of how the soleus moves. Hamilton’s method flips that upside down and makes the soleus use as much energy as possible for a long duration.
“The soleus pushup looks simple from the outside, but sometimes what we see with our naked eye isn’t the whole story. It’s a very specific movement that right now requires wearable technology and experience to optimize the health benefits,” said Hamilton.
Additional publications are in the works focused on how to instruct people to properly learn this singular movement, but without the sophisticated laboratory equipment used in this latest study.
The researchers are quick to point out that this is not some new fitness tip or diet of the month. It’s a potent physiological movement that capitalizes on the unique features of the soleus.
Potential first step toward a health care breakthrough
Hamilton calls it the “most important study” ever completed at his Metabolic Innovations lab at UH and said the discovery could be a solution to a variety of health problems caused by spending hours each day living with muscle metabolism that is too low, caused by inactivity. The average American sits about 10 hours a day.
Regardless of a person’s level of physical activity, too much sitting has been shown to increase the risk of heart disease, diabetes, dementia and more. Over half of all American adults, and 80% of people over 65, are living with the metabolic problems caused by either diabetes or prediabetes.
Having a low metabolic rate while seated is especially troublesome for people who are at high risk for age-associated metabolic diseases such as metabolic syndrome and type 2 diabetes.
Hamilton said inactive muscles require less energy than most people seem to understand, saying it’s “one of the most fundamental, yet overlooked issues” guiding the way toward discovering metabolic solutions to assist in preventing some age associated chronic diseases.
See also
“All of the 600 muscles combined normally contribute only about 15% of the whole-body oxidative metabolism in the three hours after ingesting carbohydrate. Despite the fact that the soleus is only 1% the body weight, it is capable of raising its metabolic rate during SPU contractions to easily double, even sometimes triple, the whole-body carbohydrate oxidation.
We are unaware of any existing or promising pharmaceuticals that come close to raising and sustaining whole-body oxidative metabolism at this magnitude.”
Source: University of Houston
Contact: Laurie Fickman – University of Houston
Image: The image is credited to University of Houston
Original Research: Open access.
“A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation” by Marc Hamilton et al. iScience
Abstract
A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation
Slow oxidative muscle, most notably the soleus, is inherently well equipped with the molecular machinery for regulating blood-borne substrates.
However, the entire human musculature accounts for only ∼15% of the body’s oxidative metabolism of glucose at the resting energy expenditure, despite being the body’s largest lean tissue mass.
We found the human soleus muscle could raise local oxidative metabolism to high levels for hours without fatigue, during a type of soleus-dominant activity while sitting, even in unfit volunteers. Muscle biopsies revealed there was minimal glycogen use.
Magnifying the otherwise negligible local energy expenditure with isolated contractions improved systemic VLDL-triglyceride and glucose homeostasis by a large magnitude, e.g., 52% less postprandial glucose excursion (∼50 mg/dL less between ∼1 and 2 h) with 60% less hyperinsulinemia.
Targeting a small oxidative muscle mass (∼1% body mass) with local contractile activity is a potent method for improving systemic metabolic regulation while prolonging the benefits of oxidative metabolism.
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It’s been linked to cancer, diabetes, and cardiovascular disease. In this latest meta-analysis, Daniela Schmid and Michael F.
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We know we need to exercise for our health, but a lifelong exercise habit may also help us feel younger and stay stronger well into our senior years.
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One of the most important benefits of exercise is in how it reduces our risk of developing a number of types of cancer — especially colorectal cancer, which according to some estimates is the malignancy most influenced by physical activity.
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‘Special’ Muscle Can Promote Glucose and Fat Burning to Fuel Metabolism for Hours While Sitting
By Neuroscience Newsneurosciencenews.com
6 min
View Original
Summary: The pioneering “soleus pushup” effectively elevates muscle metabolism for hours, even when sitting.
Source: University of Houston
From the same mind whose research propelled the notion that “sitting too much is not the same as exercising too little,” comes a groundbreaking discovery set to turn a sedentary lifestyle on its ear: The soleus muscle in the calf, though only 1% of your body weight, can do big things to improve the metabolic health in the rest of your body if activated correctly.
And Marc Hamilton, professor of Health and Human Performance at the University of Houston, has discovered such an approach for optimal activation – he’s pioneering the “soleus pushup” (SPU) which effectively elevates muscle metabolism for hours, even while sitting. The soleus, one of 600 muscles in the human body, is a posterior leg muscle that runs from just below the knee to the heel.
Published in the journal iScience, Hamilton’s research suggests the soleus pushup’s ability to sustain an elevated oxidative metabolism to improve the regulation of blood glucose is more effective than any popular methods currently touted as a solution including exercise, weight loss and intermittent fasting. Oxidative metabolism is the process by which oxygen is used to burn metabolites like blood glucose or fats, but it depends, in part, on the immediate energy needs of the muscle when it’s working.
“We never dreamed that this muscle has this type of capacity. It’s been inside our bodies all along, but no one ever investigated how to use it to optimize our health, until now,” said Hamilton. “When activated correctly, the soleus muscle can raise local oxidative metabolism to high levels for hours, not just minutes, and does so by using a different fuel mixture.”
Muscle biopsies revealed there was minimal glycogen contribution to fueling the soleus. Instead of breaking down glycogen, the soleus can use other types of fuels such as blood glucose and fats. Glycogen is normally the predominant type of carbohydrate that fuels muscular exercise.
“The soleus’ lower-than-normal reliance on glycogen helps it work for hours effortlessly without fatiguing during this type of muscle activity, because there is a definite limit to muscular endurance caused by glycogen depletion,” he added. “As far as we know, this is the first concerted effort to develop a specialized type of contractile activity centered around optimizing human metabolic processes.”
When the SPU was tested, the whole-body effects on blood chemistry included a 52% improvement in the excursion of blood glucose (sugar) and 60% less insulin requirement over three hours after ingesting a glucose drink.
The new approach of keeping the soleus muscle metabolism humming is also effective at doubling the normal rate of fat metabolism in the fasting period between meals, reducing the levels of fat in the blood (VLDL triglyceride).
The Soleus Pushup
Building on years of research, Hamilton and his colleagues developed the soleus pushup, which activates the soleus muscle differently than when standing or walking. The SPU targets the soleus to increase oxygen consumption – more than what’s possible with these other types of soleus activities, while also being resistant to fatigue.
Marc Hamilton, professor of Health and Human Performance at the University of Houston, is pioneering the “soleus pushup” for the calf muscle that is only 1% of your body weight, but can improve the metabolic health in the rest of your body if activated correctly. Credit: University of Houston
So, how do you perform a soleus pushup?
In brief, while seated with feet flat on the floor and muscles relaxed, the heel rises while the front of the foot stays put. When the heel gets to the top of its range of motion, the foot is passively released to come back down. The aim is to simultaneously shorten the calf muscle while the soleus is naturally activated by its motor neurons.
While the SPU movement might look like walking (though it is performed while seated) it is the exact opposite, according to the researchers. When walking, the body is designed to minimize the amount of energy used, because of how the soleus moves. Hamilton’s method flips that upside down and makes the soleus use as much energy as possible for a long duration.
“The soleus pushup looks simple from the outside, but sometimes what we see with our naked eye isn’t the whole story. It’s a very specific movement that right now requires wearable technology and experience to optimize the health benefits,” said Hamilton.
Additional publications are in the works focused on how to instruct people to properly learn this singular movement, but without the sophisticated laboratory equipment used in this latest study.
The researchers are quick to point out that this is not some new fitness tip or diet of the month. It’s a potent physiological movement that capitalizes on the unique features of the soleus.
Potential first step toward a health care breakthrough
Hamilton calls it the “most important study” ever completed at his Metabolic Innovations lab at UH and said the discovery could be a solution to a variety of health problems caused by spending hours each day living with muscle metabolism that is too low, caused by inactivity. The average American sits about 10 hours a day.
Regardless of a person’s level of physical activity, too much sitting has been shown to increase the risk of heart disease, diabetes, dementia and more. Over half of all American adults, and 80% of people over 65, are living with the metabolic problems caused by either diabetes or prediabetes.
Having a low metabolic rate while seated is especially troublesome for people who are at high risk for age-associated metabolic diseases such as metabolic syndrome and type 2 diabetes.
Hamilton said inactive muscles require less energy than most people seem to understand, saying it’s “one of the most fundamental, yet overlooked issues” guiding the way toward discovering metabolic solutions to assist in preventing some age associated chronic diseases.
See also
“All of the 600 muscles combined normally contribute only about 15% of the whole-body oxidative metabolism in the three hours after ingesting carbohydrate. Despite the fact that the soleus is only 1% the body weight, it is capable of raising its metabolic rate during SPU contractions to easily double, even sometimes triple, the whole-body carbohydrate oxidation.
We are unaware of any existing or promising pharmaceuticals that come close to raising and sustaining whole-body oxidative metabolism at this magnitude.”
About this metabolism research news
Author: Laurie FickmanSource: University of Houston
Contact: Laurie Fickman – University of Houston
Image: The image is credited to University of Houston
Original Research: Open access.
“A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation” by Marc Hamilton et al. iScience
Abstract
A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation
Slow oxidative muscle, most notably the soleus, is inherently well equipped with the molecular machinery for regulating blood-borne substrates.
However, the entire human musculature accounts for only ∼15% of the body’s oxidative metabolism of glucose at the resting energy expenditure, despite being the body’s largest lean tissue mass.
We found the human soleus muscle could raise local oxidative metabolism to high levels for hours without fatigue, during a type of soleus-dominant activity while sitting, even in unfit volunteers. Muscle biopsies revealed there was minimal glycogen use.
Magnifying the otherwise negligible local energy expenditure with isolated contractions improved systemic VLDL-triglyceride and glucose homeostasis by a large magnitude, e.g., 52% less postprandial glucose excursion (∼50 mg/dL less between ∼1 and 2 h) with 60% less hyperinsulinemia.
Targeting a small oxidative muscle mass (∼1% body mass) with local contractile activity is a potent method for improving systemic metabolic regulation while prolonging the benefits of oxidative metabolism.
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