"Of the greatest importance in deficiency of glycogen in the liver is the impairment of the hepatic function of detoxication. Experimentally, Sansum and Woodyatt found that animals treated with phlorhizin are easier to kill with chloroform than are normal animals ; while Davis and Bollman noticed that such hepatic poisons as chloroform, carbon tetrachloride and a reduced phosphorus are more effective in animals with a reduced glycogen content of the liver. Guttmann found that undernutrition markedly increases the incidence of arsphenamine icterus. Baehr and Klemperer observed similarly that diabetic patients on a low carbohydrate diet stood arsenical therapy poorly and frequently developed jaundice."
"There are several ways in which dextrose, and the same applies to glycogen, has been proved to have an allaying action in hepatic injury. In the first place, dextrose neutralizes many exogenous and endogenous toxins. This may be accomplished by partial oxidation to less toxic compounds or by complete oxidation to carbon dioxide and water. Another path lies through conjugation to nontoxic glycuronates. The latter is known to occur with cresols, phenols, salicylates, camphor, and many substances containing these compounds (e.g., morphine). Confirmatively, Becher found that the phenols of the blood are increased, and Sauer has shown that the glycuronic acid of the urine is diminished in patients suffering from various types of diseases of the liver. In the second place, under carbohydrate therapy, repair of the injured liver proceeds much more rapidly. This was demonstrated in dogs by Davis, Hall and after poisoning with chloroform and by Whipple Ravdin in experimental obstructive jaundice following removal of the ligature of the common bile duct."
"SUMMARY
1. The presence of a certain amount of glycogen in the liver is essential for the proper functioning of this organ.
2. In diseases of the liver, insufficient gluconeogenesis causes "internal" carbohydrate starvation, which results in a reduction of hepatic glycogen, probably largely through depletion of that part of it which serves as a storage form of carbohydrate.
3. Both in experimental animals with hepatic damage and in patients with diseases of the liver, it is possible by administration of suitable amounts of dextrose to relieve the internal shortage of carbohydrate and, as a result of this, to bring about glycogen storage.
4. Dextrose therapy is indicated in all cases of primary and secondary hepatic disease.
5. Oral administration of dextrose is the method of choice unless contraindications are present."
One of the most important endogenous substances for detoxification of the liver is glucaric acid (glucoronidaton). It is derived from glucose, and in german it's also called sugar acid.
A single apple contains up to 150mg of glucaric acid. Glucose intake boosts glucaric acid synthesis. Intake of 30-50g of dextrose per day is probably helpful to support liver detoxification and sufficient glycogen storage.
"There are several ways in which dextrose, and the same applies to glycogen, has been proved to have an allaying action in hepatic injury. In the first place, dextrose neutralizes many exogenous and endogenous toxins. This may be accomplished by partial oxidation to less toxic compounds or by complete oxidation to carbon dioxide and water. Another path lies through conjugation to nontoxic glycuronates. The latter is known to occur with cresols, phenols, salicylates, camphor, and many substances containing these compounds (e.g., morphine). Confirmatively, Becher found that the phenols of the blood are increased, and Sauer has shown that the glycuronic acid of the urine is diminished in patients suffering from various types of diseases of the liver. In the second place, under carbohydrate therapy, repair of the injured liver proceeds much more rapidly. This was demonstrated in dogs by Davis, Hall and after poisoning with chloroform and by Whipple Ravdin in experimental obstructive jaundice following removal of the ligature of the common bile duct."
"SUMMARY
1. The presence of a certain amount of glycogen in the liver is essential for the proper functioning of this organ.
2. In diseases of the liver, insufficient gluconeogenesis causes "internal" carbohydrate starvation, which results in a reduction of hepatic glycogen, probably largely through depletion of that part of it which serves as a storage form of carbohydrate.
3. Both in experimental animals with hepatic damage and in patients with diseases of the liver, it is possible by administration of suitable amounts of dextrose to relieve the internal shortage of carbohydrate and, as a result of this, to bring about glycogen storage.
4. Dextrose therapy is indicated in all cases of primary and secondary hepatic disease.
5. Oral administration of dextrose is the method of choice unless contraindications are present."
One of the most important endogenous substances for detoxification of the liver is glucaric acid (glucoronidaton). It is derived from glucose, and in german it's also called sugar acid.
A single apple contains up to 150mg of glucaric acid. Glucose intake boosts glucaric acid synthesis. Intake of 30-50g of dextrose per day is probably helpful to support liver detoxification and sufficient glycogen storage.
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