Haidut Interview Doctor Age Reversal - How To Accomplish Metabolic Flexibility The Key to a Longer Life (Georgi Dinkov Interview)

[HumanLife]

View: https://www.youtube.com/watch?v=hNUBxUPzQ44

 

[David PS]

@HumanLife - Thanks for the link to a new video interview. The video now has timestamps.

0:00 Podcast Intro
1:17 Georgi Dinkov Intro
03:26 What is metabolic flexibility?
14:13 Sugar, fat and ketosis
23:01 IV glucose drip in the ER
30:44 Polyunsaturated fats are toxic
37:39 Cortisol supplement recommendation
39:29 Choline and vegans
42:43 The ketogenic diet
44:46 Glucose and insulin
47:21 Glucose monitors
49:48 Vitamin E
51:38 Aspirin and Willow Bark
55:07 ATP and electron flow
56:34 Cytochrome c oxidase and copper
57:47 Willow Bark, caffeine and ephedra
58:20 Niacinamide and NAD+
1:04:17 Methylation
1:06:39 Chronic stress kills

Edit - I prefer to watch the video on YouTube. I have changed the setting at YouTube so that I can read transcript while watching the video.

 

[golder]

Wow I missed this - huge thanks!

 

[EustaceBagge]

Much thanks to @David PS and @HumanLife !

 

[akgrrrl]

Much thanks to @David PS and @HumanLife !

Yes! David PS always comes thru for members with his tips, tweaks, and technology assists

 

[-Luke-]

Good interview, although I have not yet finished listening. Thanks for sharing!

Never heard of that guy (Rosen that is, not Georgi). But he seems to be a good host. Lets his guest talk and does not interrupt.

 

[Hans]

Bro wasn't even trying.

 

[EustaceBagge]

View attachment 56633
Bro wasn't even trying.

LOL, written like this it resembles Chinese.

 

[CastorTroy]

Alias Haircut

Thanks to David PS

 

[Highserotonin90]

Are high fats suggested?

 

[geusterman]

Thanks for that one David. Really enjoyed it.

 

[-Luke-]

View attachment 56633
Bro wasn't even trying.

LOL. That happens when you trust AI and don't check the output. But I'm glad Mr. Ding Cough doesn't need an introduction.

 

[Mauritio]

LOL. That happens when you trust AI and don't check the output. But I'm glad Mr. Ding Cough doesn't need an introduction.

Mr. Ding cough doesnt even have ears on his thumbnail

 

[cs3000]

View attachment 56633
Bro wasn't even trying.

Mr. Ding cough doesnt even have ears on his thumbnail

lol hilarious

 

[David PS]

View: https://www.youtube.com/watch?v=-3xFY2dxlsk

From Dr.Joel Rosen (age reversing Doc) -
The 5 tips for achieving Metabolic Flexibility According to Georgi Dinkov's Definition of what it means to be Metabolically Flexible.

What does it mean to be Metabolic flexible?
The best example is a young, healthy child. Oxidize, which means turning the macronutrients from the food we eat into ATP, CO2, and H20 when releasing energy. The Macronutrients are made up of protein, carbohydrates, and fats; the body directly processes carbs into sugars, and dietary fat, while converting the protein we eat into sugars. They get tired much quicker, but they also recover much faster. Children process foods very quickly, they get hungry very quickly, When you don't provide them with glucose for a period of time, they get crankier, because they are switching over to burn (the oxidation) of fat. But the energy is still there. When you feed them they usually get sleeping, they easily recover, and they are up and at it again. That process degrades as age advances, which shows up as varying degrees of insulin resistance.

Even if you haven't been diagnosed as a diabetic. Accumulation of extra fat, especially around the midsection, and inability to process properly glucose. However, a metabolically flexible child can handle the process effectively. They eat sugar, and experience the effects of insulin, but don't become resistant. Something shifting us towards insulin resistance.

Enter In The Concept Of The Randle Cycle:
On the very basis, there is a competition between glucose and free fatty acids, for oxidation, or being used as the primary fuel. They compete for co-factors and basically attention. When supplied with both fats and carbohydrates, it depends on the relative proportions and relative amounts for each. The level of metabolic flexibility varies from person to person.

If the body is oxidizing fats, and the glucose amount is above what the cell can process, because the cell is preoccupied with burning fats, it has to go somewhere. Build up of these reduced equivalent, because the metabolic fire is already burning, The other pathway for glucose to go is to make (synthesize) fats. Need oxidized factors, NAD+, FAD+, NADP+ Emergency oxidant to accept the hydrogen electron, pyruvate is usedPyruvate then converts into Lactate A subset of people can process fatty acids perfectly fine, but when you give them too much sugar to process, they lose their metabolic flexibility and become insulin-resistant.

What is happening here? Oversupply of fatty acids, cannot metabolize glucose effectively. MUST REIGN THAT IN TO FIX THAT. Must lower the oversupply of fatty acids and lipolysis (the burning of it) In young kids, eating sugar/glucose after a long bout of fasting, or burning fat, will lower lipolysis, because insulin is released, as children are STILL METABOLICALLY FLEXIBLE Because insulin is ANTI LIPOLYTIC (against fat burning), and because kids are metabolically flexible, the fat burning is turned off, and the glucose that the kid just ate, is able to be prioritized and burnt. That should happen as we get older, but doesn't, and is called = INSULIN RESISTANCE When NOT metabolically flexible, you will not lower lipolysis by eating and having to burn glucose, Therefore glucose and insulin can be constantly elevated, Cannot switch over to burning glucose like young children are,Metabolically inflexibility,

Limit oversupply of fat, to the cellor limit their oxidation, fatty acid inhibitors,or beta-oxidation inhibitors, beta-blockers, When you do that, studies show that cells revert back to burning glucose, Giving the cell a break by limiting the oversupply of fat. Oversupply of fat, and for as long as that is happening you will remain metabolically inflexible. This leads to the accumulation of fat, Combine that with Stress, which causes chronic cortisol and adrenaline to be higher than optimal and the main role of adrenaline is to increase lipolysis, So Stress is associated with supply fat, Underlying problem, chronic stress, chronic inflammation Metabolic in origin and encouraging studies demonstrating that they are reversible

Formula For Success: Typically equal ratios of Protein: Carbs: Fats, 33% of each
Limit Seed oils/P FA's
Mostly Saturated Fats, of animal origin