Enclomiphene Hydrochloride

[James_001]

"Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. Enclomiphene is the trans-isomer of clomiphene, which is about a 60-40 mix of trans (Enclomiphene) and cis (Zuclomiphene). While enclomiphene (trans-clomiphene) is an estrogen antagonist, zuclomiphene (cis-clomiphene) is a mixed agonist, responsible for the estrogenic activity and therefore the common side effects sometimes seen in males. The enclomiphene isomer is responsible for the anti-estrogen activity and the restoration of ones hypothalamic–pituitary–gonadal axis. In recent clinical trials, enclomiphene increased serum LH and FSH with concomitant increases in testosterone in men with secondary hypogonadism. Enclomiphene showed overall better results than testosterone gels, which raise serum testosterone but can lower LH and FSH at the same time."

http://www.sigmaaldrich.com/catalog/product/sigma/sml0719?lang=en&region=US

Any reason anyone can think of why this would be toxic/not work?

I may give this a try if anyone more experienced in biochemistry can comment on its safety.

Thanks

 

[Koveras]

Someone made the comment that it takes about 20 years on the market for the full side effect profile of a drug to be known.

Very new drug, very few studies, many unknowns.

Structurally similar to a compound (clomiphene) with many potential adverse effects - regardless of their claim that it does not have any estrogen agonist properties.