ATP
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- Joined
- Oct 15, 2015
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- 279
These two guys along with Lustig are the most prominent individuals that promote the anti-sugar sentiment.
View: https://www.youtube.com/watch?v=5jBsWbDGtWU
His theory on fructose metabolism
- The phosphorylation of fructose to fructose-1-phosphate by fructokinase significantly lowers ATP and intracellular phosphate concentrations.
- The rate at which ATP concentrations reduce is so fast that the cell is unable to regenerate ATP levels, AMP deaminase is activated which catalyses AMP to IMP and ultimately uric acid.
- The uric acid inhibits AMP-activated protein kinase, which coupled with the low AMP levels further halts the regeneration of ATP.
- The metabolism of fructose via fructokinase leads to many negative effects such as increased oxidative stress (NADPH oxidase), inhibition of aconitase (Krebs cycle) with an increase in glycolysis and lactate production.
Even though muscle and adipose tissue utilise hexokinase to metabolise fructose, other extrahepatic tissue such as the brain utilises fructokinase.
The body can also endogenously produce fructose from glucose (polyol pathway), he claims that there is no distinction between the negative effects of dietary fructose and endogenously synthesised fructose.
His theory is essentially the metabolism of fructose leads to mitochondrial dysfunction, reduced oxidative phosphorylation, and ultimately a low energy state.
What does everyone think about his claim about fructose?
View: https://www.youtube.com/watch?v=5jBsWbDGtWU
His theory on fructose metabolism
- The phosphorylation of fructose to fructose-1-phosphate by fructokinase significantly lowers ATP and intracellular phosphate concentrations.
- The rate at which ATP concentrations reduce is so fast that the cell is unable to regenerate ATP levels, AMP deaminase is activated which catalyses AMP to IMP and ultimately uric acid.
- The uric acid inhibits AMP-activated protein kinase, which coupled with the low AMP levels further halts the regeneration of ATP.
- The metabolism of fructose via fructokinase leads to many negative effects such as increased oxidative stress (NADPH oxidase), inhibition of aconitase (Krebs cycle) with an increase in glycolysis and lactate production.
Even though muscle and adipose tissue utilise hexokinase to metabolise fructose, other extrahepatic tissue such as the brain utilises fructokinase.
The body can also endogenously produce fructose from glucose (polyol pathway), he claims that there is no distinction between the negative effects of dietary fructose and endogenously synthesised fructose.
His theory is essentially the metabolism of fructose leads to mitochondrial dysfunction, reduced oxidative phosphorylation, and ultimately a low energy state.
What does everyone think about his claim about fructose?