It's not just the glycine! Pro-metabolic peptides in gelatin.

[Mauritio]

Many people commonly attribute gelatin's anti-inflammatory effects solely to the amino acid glycine, and perhaps also to proline or hydroxyproline. However, it appears that gelatin/collagen contains intriguing peptides with a multitude of unique benefits.

This supports the idea of favoring gelatin consumption over relying solely on glycine. According to Peat, the advantages of gelatin on arthritis may not necessarily arise from its impact on collagen but likely from the anti-inflammatory properties of its amino acids. Considering these studies, it could equally be attributed to the peptides, given their potent anti-inflammatory effects.

In this particular study, it was demonstrated that bovine collagen peptides significantly reduced TLR4, COX2, NO, and various pro-inflammatory cytokines.

Beyond reducing intestinal inflammation, the gelatin peptides also exhibited the ability to enhance components such as occludin, contributing to the rebuilding of the intestinal mucosa. Additionally, they influenced the microbiome by increasing the presence of beneficial bacteria, such as Akkermansia."

- The Anti-Inflammatory Effect of Bovine Bone-Gelatin-Derived Peptides in LPS-Induced RAW264.7 Macrophages Cells and Dextran Sulfate Sodium-Induced C57BL/6 Mice


Here is another study on those peptides:
- Spectrum-Effect Relationships between High-Performance Liquid Chromatography (HPLC) Fingerprints and the Antioxidant and Anti-Inflammatory Activities of Collagen Peptides

 

[CastorTroy]

I wonder if gelatin obtained from animal's skin has the same benefits.

 

[Mauritio]

I wonder if gelatin obtained from animal's skin has the same benefits.

Not sure. But does animal skin not have a high histamine content? I thought i read something about that.

 

[GTW]

Similar benefits are claimed for consuming glutamine and\or N-acetyl Glucosamine alone.

Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals without symptoms of arthritis: A randomized double-blind placebo-controlled clinical study - PubMed

The present study aimed to evaluate the effect of N-acetyl-glucosamine (GlcNAc) on the joint health of healthy individuals without arthritic symptoms. A randomized double-blind placebo-controlled clinical trial was performed to investigate the effect of oral administration of a GlcNAc-containing...

pubmed.ncbi.nlm.nih.gov

>N-acetyglucosamine (GlcNAc) is a triple modulator of inflammation, myelination and neurodegeneration. GlcNAc promotes biosynthesis of Asn (N)-linked-glycans, which interact with galectins to co-regulate the clustering/signaling/endocytosis of multiple glycoproteins simultaneously. In mice, GlcNAc crosses the blood brain barrier to raise N-glycan branching, suppress inflammatory demyelination by T and B cells and trigger stem/progenitor cell mediated myelin repair.

N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial - Journal of Neuroinflammation

Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. While B cell depletion and blockade/sequestration of T and B cells potently reduces episodic relapses, they...

jneuroinflammation.biomedcentral.com