Cellular repair growth & replication needs nucleotides as building substance, base of DNA/RNA.
Cells salvage their nucleotide needs (we ingest RNA from foods and re-incorporate it), or cells synthesise some of it (as purines and pyrimidines)
talking about ingesting nucleotides and importance of mitochondria / ATP (core of rays approach to health) in the 1970s
4 minutes in
View: https://www.youtube.com/watch?v=myD7ED6QAxQ#t=4m15s
^ Along with the clinical health improvements he talked about feeling warmth & ability to tolerate cold from dietary RNA,
confirmed in mice study last year, where adding adenosine in diet improved metabolic rate, heat production, body composition https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250134/
(Think human dose comes to ~750mg -1g? will double check)
Temperature differences in center pic.
Interestingly less fat more muscle on slightly higher food intake too (higher metabolic rate)
ATP = Adenosine Triphosphate
Some parts of the body rely way more on dietary intake of nucleotides than others,
especially rapidly replicating ones as the endogenous synthesis alone cant keep up with the high demand.
Ongoing boost from diet especially needed for small intestine cells, immune cells, some brain cells, and i think liver cells.
E.g if you feed someone on low protein diet through the stomach and their immune system crashes, restoring protein doesnt help recover it enough if the diet doesnt contain nucleotides. only nucleotides fully restore the immune system because immune cells rely on the dietary boost.
- uridine (UMP) - cytidine
- Adenosine (AMP) - inosine
- Adenine - thymidine
- guanosine - guanine
- hypoxanthine - xanthine
nice writeup of nucleotides here Chapter 1 | Feel Good Nucleotides
Highest sources are animal meats (primarily hearts & sardines), and brewers yeast (typically ~8% RNA. i think highest nucleotide is adenosine in this) (and uridine/inosine supps)
Theres a study showing +2g a day in humans was safe for uric acid levels (gout potential), but 2.9g tipped over to too much
Some suggestion its best to get a mix instead of supplementing only 1 single nucleotide, as in vitro cells can still grow with this but fail to replicate (the single nucleotide signals endogenous production to stop, so imbalance = cell stops replication). unless specifically trying to stop proliferation maybe. But probably doesnt work the same in vivo at regular doses (have seen wound healing accelerates on only uridine for example, feeding solely adenosine didnt seem to be a problem in mice study with their muscle gain) Nucleotide imbalance decouples cell growth from cell proliferation
will add some more studies
Cells salvage their nucleotide needs (we ingest RNA from foods and re-incorporate it), or cells synthesise some of it (as purines and pyrimidines)
Benjamin Frank, one of the early pioneers who used dietary nucleotides for healthCells must acquire sufficient levels of each nucleotide species both for RNA synthesis and biomass production, and to ensure efficient and accurate DNA replication during S phase. Obtaining nucleotides for efficient RNA and DNA synthesis can be particularly limiting for cell proliferation
talking about ingesting nucleotides and importance of mitochondria / ATP (core of rays approach to health) in the 1970s
4 minutes in
View: https://www.youtube.com/watch?v=myD7ED6QAxQ#t=4m15s
^ Along with the clinical health improvements he talked about feeling warmth & ability to tolerate cold from dietary RNA,
confirmed in mice study last year, where adding adenosine in diet improved metabolic rate, heat production, body composition https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250134/
(Think human dose comes to ~750mg -1g? will double check)
Temperature differences in center pic.
Interestingly less fat more muscle on slightly higher food intake too (higher metabolic rate)
Benjamin frank mentioned using 1g in his clinical practice to help parkinsons patients in that videoIn conclusion, dietary AMP supplementation increases the food intake and reduces the body fat content of mice without affecting body weight and organs index. In addition, AMP reduces adipose content and increases lean meat content by promoting BAT activation and thermogenesis without affecting body weight.
Meanwhile, AMP treatment also significantly increased the energy metabolism of mice, especially the basic energy expenditure.
ATP = Adenosine Triphosphate
Some parts of the body rely way more on dietary intake of nucleotides than others,
especially rapidly replicating ones as the endogenous synthesis alone cant keep up with the high demand.
Ongoing boost from diet especially needed for small intestine cells, immune cells, some brain cells, and i think liver cells.
E.g if you feed someone on low protein diet through the stomach and their immune system crashes, restoring protein doesnt help recover it enough if the diet doesnt contain nucleotides. only nucleotides fully restore the immune system because immune cells rely on the dietary boost.
Although the intestine can synthesize NT from amino acids and other precursors and are thus not [labelled] essential nutrients, NT synthesis appears to be limited and dependent on an exogenous supply of NT
Because the de novo synthesis is metabolically costly, a dietary source of NT may optimize the function of rapidly dividing tissues like the intestine, especially during periods of food deprivation or stress.
- uridine (UMP) - cytidine
- Adenosine (AMP) - inosine
- Adenine - thymidine
- guanosine - guanine
- hypoxanthine - xanthine
nice writeup of nucleotides here Chapter 1 | Feel Good Nucleotides
Highest sources are animal meats (primarily hearts & sardines), and brewers yeast (typically ~8% RNA. i think highest nucleotide is adenosine in this) (and uridine/inosine supps)
Theres a study showing +2g a day in humans was safe for uric acid levels (gout potential), but 2.9g tipped over to too much
Some suggestion its best to get a mix instead of supplementing only 1 single nucleotide, as in vitro cells can still grow with this but fail to replicate (the single nucleotide signals endogenous production to stop, so imbalance = cell stops replication). unless specifically trying to stop proliferation maybe. But probably doesnt work the same in vivo at regular doses (have seen wound healing accelerates on only uridine for example, feeding solely adenosine didnt seem to be a problem in mice study with their muscle gain) Nucleotide imbalance decouples cell growth from cell proliferation
will add some more studies
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