Mito
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Key Mediterranean Diet Trial Retracted
The landmark PREDIMED randomized trial of a Mediterranean diet has been influential and highly cited since its 2013 publication in the New England Journal of Medicine. But now it has been retracted and republished after hidden protocol changes and randomization violations came to light.
The tip-off came from an analysis of randomized trials looking for improbable distributions of baseline data, with PREDIMED flagged for variables inconsistent with randomization, according to an editor's note appearing with the retraction.
https://www.nejm.org/doi/full/10.1056/NEJMc1806491
Because of irregularities in the randomization procedures, we wish to retract the following article: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90. DOI: 10.1056/NEJMoa1200303.1 We have reanalyzed the data and have published a new report: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. DOI: 10.1056/NEJMoa1800389.2
The landmark PREDIMED randomized trial of a Mediterranean diet has been influential and highly cited since its 2013 publication in the New England Journal of Medicine. But now it has been retracted and republished after hidden protocol changes and randomization violations came to light.
The tip-off came from an analysis of randomized trials looking for improbable distributions of baseline data, with PREDIMED flagged for variables inconsistent with randomization, according to an editor's note appearing with the retraction.
https://www.nejm.org/doi/full/10.1056/NEJMc1806491
Because of irregularities in the randomization procedures, we wish to retract the following article: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90. DOI: 10.1056/NEJMoa1200303.1 We have reanalyzed the data and have published a new report: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. DOI: 10.1056/NEJMoa1800389.2