(sorry for the bad english, not my 1st language)
Hi,
New Member here . I have become a big fan of peat's work especially the PUFAs . I have seen great studies been posted by @haidut for reversing chronic diseases like diabetes with simple measures like biotin, aspirin ,vitamin k2 etc. Before ray peat , i thought genetics and inheritance determine everything and you can't do much to change it (unless you go through gene therapy which to my knowledge is still in early stages) but that has changed.
I am trying to learn a bit of endocrinology though i don't have a medical background ( i know ray doesn't believe in 'lock and key receptors') but i am seeing that the protective and anti-inflammatory of DHT are due its metabolite 3-beta diol
which wikipedia says is an estrogen and has greater affinity for ER-beta receptors than estradiol !!
This study says that the protective effects of DHT are due to its action via ER-beta receptors by 3-beta diol.
The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor bet... - PubMed - NCBI
Since , estrogen is the enemy (it's excess), my question is that can two compounds ,say 3-beta diol and estradiol , act via same receptors(proteins) , ER-beta here and have different effects? Though DHT can't be aromatized but still can be turned into potent estrogens, so doesn't that make DHT dangerous also ?
Thanks
Hi,
New Member here . I have become a big fan of peat's work especially the PUFAs . I have seen great studies been posted by @haidut for reversing chronic diseases like diabetes with simple measures like biotin, aspirin ,vitamin k2 etc. Before ray peat , i thought genetics and inheritance determine everything and you can't do much to change it (unless you go through gene therapy which to my knowledge is still in early stages) but that has changed.
I am trying to learn a bit of endocrinology though i don't have a medical background ( i know ray doesn't believe in 'lock and key receptors') but i am seeing that the protective and anti-inflammatory of DHT are due its metabolite 3-beta diol
which wikipedia says is an estrogen and has greater affinity for ER-beta receptors than estradiol !!
This study says that the protective effects of DHT are due to its action via ER-beta receptors by 3-beta diol.
The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor bet... - PubMed - NCBI
Since , estrogen is the enemy (it's excess), my question is that can two compounds ,say 3-beta diol and estradiol , act via same receptors(proteins) , ER-beta here and have different effects? Though DHT can't be aromatized but still can be turned into potent estrogens, so doesn't that make DHT dangerous also ?
Thanks