tomisonbottom
Member
- Joined
- Apr 17, 2013
- Messages
- 920
As Ray said, the official story on cancer and many other conditions thought to be genetic is slowly changing. The powers that be won't admit overnight that genetics has little (if anything) to do with cancer, but the evidence for metabolic dysfunction as a cause of cancer is slowly building up. Last year, I posted a seminal study claiming that the Warburg "effect" is not just an effect but a driver and cause of cancer development. Now, this study adds to the evidence that cellular stress, especially in the mitochondria, is sufficient to cause and drive cancer progression.
Mitochondrial stress-induced p53 attenuates HIF-1α activity by physical association and enhanced ubiquitination
http://medicalxpress.com/news/2016-07-team-mitochondrial-stress-cancer-related-metabolic.html
"...Yet new findings from University of Pennsylvania researchers suggest that such efforts might have missed a key pathway that enables the changes in metabolism that benefit tumors. Their work finds that mitochondrial stress alone can trigger metabolic shifts through a pathway that involves p53, a protein widely known to play multiple important roles in cancer."
"...Further investigation revealed that p53 reduced HIF-1α levels in the nucleus and the cytoplasm of cells and that genes responsive to HIF-1α were blunted when mitochondrial DNA was depleted. Notably, they found that the expression of several genes involved with glycolysis, a metabolic process by which cells break down sugar to make energy, jumped dramatically in cells in which mtDNA was depleted. Some of these were the same genes that HIF-1α normally regulates, pointing to mitochondrial stress as a similar but completely separate pathway by which a metabolic shift can occur in cancer cells."
I just came across this article > Cancer as a mitochondrial metabolic disease:
Cancer as a mitochondrial metabolic disease
Genes, Respiration, Viruses, and Cancer - Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer - Seyfried - Wiley Online Library
Tried searching the forum and didn't see it posted yet, so thought I'd add it to the thread.
Lots of great references to other works he's done at the bottom too.