M
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hello, I have battled with anxiety for so long. I have found the cause but not what causes it. My anxiety is caused by excess CRH-CRHR1 signaling. CRHR1 is activated through the binding of CRH (Corticotropin-releasing hormone). Im not sure what causes it but I have narrowed it down to 3 plausible causes:
1. A hypermorphic mutation causes an increase in normal gene function.[1] Hypermorphic alleles are gain of function alleles. A hypermorph can result from an increase in gene dose (a gene duplication), from increased mRNA or protein expression, or constitutive protein activity.
Muller's morphs - Wikipedia
2. CRH tumor
Ectopic corticotropin-releasing hormone (CRH) syndrome from metastatic small cell carcinoma: a case report and review of the literature
3. autoimmune disease (least plausible)
Autoimmune disease - Wikipedia
Im just looking for ways to decrease CRH. At the moment I have tried all supplements that has an decrease effect on CRH like St johns Wort, ginkgo biloba, lithium and some more but they are weak. I need a man-made drug. I have found one which is called carbamazepine it directly inhibit hypothalamus crh straight from the source. So hopefully this will be the end of my anxiety.
1. A hypermorphic mutation causes an increase in normal gene function.[1] Hypermorphic alleles are gain of function alleles. A hypermorph can result from an increase in gene dose (a gene duplication), from increased mRNA or protein expression, or constitutive protein activity.
Muller's morphs - Wikipedia
2. CRH tumor
Ectopic corticotropin-releasing hormone (CRH) syndrome from metastatic small cell carcinoma: a case report and review of the literature
3. autoimmune disease (least plausible)
Autoimmune disease - Wikipedia
Im just looking for ways to decrease CRH. At the moment I have tried all supplements that has an decrease effect on CRH like St johns Wort, ginkgo biloba, lithium and some more but they are weak. I need a man-made drug. I have found one which is called carbamazepine it directly inhibit hypothalamus crh straight from the source. So hopefully this will be the end of my anxiety.