Low Cholesterol Ups Cancer Risk - Role Of Pregnenolone

haidut

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Ray has written about how "anything that lowers cholesterol will increase the risk of cancer". I did some digging on that and it seems that he is right on the money on this one. Here is a study confirming his view:
http://www.sciencedaily.com/releases/20 ... 113713.htm
"...Low LDL cholesterol in patients with no history of taking cholesterol-lowering drugs predates cancer risk by decades, suggesting there may be some underlying mechanism affecting both cancer and low LDL cholesterol that requires further examination, according to new research."

I found a study on PubMed that claims this increased cancer risk is mainly due to decreased synthesis of pregnenolone. So, another point for Ray and his writings that pregnenolone has strong anti-cancer properties.
Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. - PubMed - NCBI

"...Low serum levels of P in aging and the increases of cancer and behavioral disorders in individuals receiving drugs that block synthesis of cholesterol, the immediate precursor of P, suggest possible clinical utility for P."

And here is the longer discussion at the end of the study:

"...If P PS, and steroids derived from them should become inadequately available, as during aging, stress, or disease, degenerative processes may be initiated upon occurrence of functional demands that require enhanced metabolic responses and genomic transcription to take place. Degenerative processes may not become irreversible as long as affected cells still possess receptors for the substances in question. Restoring adequate levels of rate-limiting steroids might permit a measure of recovery to take place. In this regard, it is of interest that greatly reduced serum levels of P and 17a-hydroxypregnenolone were found in aged patients with Alzheimer disease the decreased levels probably being typical of aging nondemented patients and not specific for Alzheimer disease. Further study will reveal whether these results are indicative of an embarrassment of P synthesis and, if so, at which locus the rate limitation occurs. If the synthesis of P were to become limiting in aging and in other conditions, it would be expected that inhibition of synthesis of its sole precursor, cholesterol would further compromise the overall steroid economy and that individuals to whom are given drugs that block cholesterol synthesis would show adverse effects. Indeed, studies have shown that such treatments, while ameliorating cardiac symptoms, actually have resulted in increases in noncardiac deaths, including cancer and nervous system-related phenomena such as accidents, suicides, and violence. Perhaps administration of P together with cholesterol-lowering drugs would ameliorate the above undesirable effects. Detailed evaluation of steroid metabolism in patients receiving such drugs is recommended."
 
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piotr_zarach

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Great info ! So in addition to fructose and the cholesterol,caffeine, coconut oil what we should take in order to achieve high levels of these hormones?
 
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When isn't Peat on the money! He said cholesterol is also protective in its own right.
 

piotr_zarach

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I found this words of Albert Hofmann (lived 102 years in full mental capacity) :

"Instead, Hofmann revealed the secret of his longevity was the two raw eggs he eats with his muesli for breakfast.

"In an egg there is everything a being needs to develop -- vitamins, minerals and hormones," he said. "




Do raw eggs contain some sort of form of progesterone or pregnenolone?

Any evidence of this theory ?


http://www.maps.org/media/view/secret_o ... iscoverer/
 
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haidut

haidut

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piotr_zarach said:
I found this words of Albert Hofmann (lived 102 years in full mental capacity) :

"Instead, Hofmann revealed the secret of his longevity was the two raw eggs he eats with his muesli for breakfast.

"In an egg there is everything a being needs to develop -- vitamins, minerals and hormones," he said. "




Do raw eggs contain some sort of form of progesterone or pregnenolone?

Any evidence of this theory ?


http://www.maps.org/media/view/secret_o ... iscoverer/

I suspect Hoffman has a point. Here is another study in worms, which is befitting the thread:
http://newsroom.ucla.edu/portal/ucla/ti ... 21986.aspx
http://www.plosone.org/article/info%3Ad ... ne.0029984

The study claims that it is the alcohol that resulted in extended lifespan, but I suspect it was the cholesterol, since that is what led the researchers to experiment with alcohol (ethanol) to start with. Cholesterol on its own increased lifespan as well.

In terms of increasing pregnenolone, I think increasing cholesterol intake is probably your best bet and then taking thyroid to stimulate the conversion into pregnenolone. High dose caffeine, aspirin, and niacinamide should be able to mimic the effects of thyroid if you don't want to take hormones.
Finally, here is a very interesting discussion on how eating nothing but eggs will not only be good for your cholesterol but may also result in 9% reduction of belly fat.
http://suppversity.blogspot.com/2012/02 ... -your.html
 

piotr_zarach

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haidut said:
piotr_zarach said:
I found this words of Albert Hofmann (lived 102 years in full mental capacity) :

"Instead, Hofmann revealed the secret of his longevity was the two raw eggs he eats with his muesli for breakfast.

"In an egg there is everything a being needs to develop -- vitamins, minerals and hormones," he said. "




Do raw eggs contain some sort of form of progesterone or pregnenolone?

Any evidence of this theory ?


http://www.maps.org/media/view/secret_o ... iscoverer/

I suspect Hoffman has a point. Here is another study in worms, which is befitting the thread:
http://newsroom.ucla.edu/portal/ucla/ti ... 21986.aspx
http://www.plosone.org/article/info%3Ad ... ne.0029984

The study claims that it is the alcohol that resulted in extended lifespan, but I suspect it was the cholesterol, since that is what led the researchers to experiment with alcohol (ethanol) to start with. Cholesterol on its own increased lifespan as well.

In terms of increasing pregnenolone, I think increasing cholesterol intake is probably your best bet and then taking thyroid to stimulate the conversion into pregnenolone. High dose caffeine, aspirin, and niacinamide should be able to mimic the effects of thyroid if you don't want to take hormones.
Finally, here is a very interesting discussion on how eating nothing but eggs will not only be good for your cholesterol but may also result in 9% reduction of belly fat.
http://suppversity.blogspot.com/2012/02 ... -your.html


I will try to further test the eating two raw eggs (from a local farmer) together with sweetened instant coffee. Until now, each time I did it all experienced increased concentration on the task that I had to do, feeling calm and generally feeling OK.

I think that Sir Albert was right that in raw eggs are hormones (question what and in what quantities).
So far I found only study showing how during the development of the embryo changes to the system Progesterone / Testosterone / Estrogen.
 

Suikerbuik

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Yeah that's true, since all multi-celluar organism regulate many things by hormones, although birds aren't genetically the same as humans, many organisms even plants do share many of the same genes. So hormones are part of every multi cellular organism (I mean living and moving animals, not so aware of many plants containing progestrone, still our pregnenolone comes from a plant precursor mainly).

Anyway how many depends of how the animal is raised, stress lowers levels significantly see:
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023824
See figure 4:
Based on this I assume yolks contain roughly ug progestrone per g yolk, testosterone 4 ng per g yolk and estrogen 2,5 ng per g yolk.
 

facesavant

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I found this words of Albert Hofmann (lived 102 years in full mental capacity) :

"Instead, Hofmann revealed the secret of his longevity was the two raw eggs he eats with his muesli for breakfast.

"In an egg there is everything a being needs to develop -- vitamins, minerals and hormones," he said. "




Do raw eggs contain some sort of form of progesterone or pregnenolone?

Any evidence of this theory ?


http://www.maps.org/media/view/secret_o ... iscoverer/
A relative ate raw eggs every day and died of a heart attack in their young 80's. that was many years ago when store purchased eggs were still trustworthy.
 
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“There has been some debate as to whether or not medications used to lower cholesterol may contribute to cancer, but the evidence so far tells us that the drugs themselves do not increase the risk of cancer. We wanted to take those medications out of the equation and just look at the link between cancer and low LDL-cholesterol itself in people who had never taken statins or other cholesterol-lowering drugs," said Paul Michael Lavigne, MD, resident, Tufts Medical Center and the study's lead investigator.

In a matched case control study, researchers used data from the Framingham Heart Study Offspring Cohort to assess the trend of low LDL-C for an extended period of time prior to cancer diagnosis.

They compared 201 cancer cases and 402 control cases that were cancer-free.

Cases were matched on factors including age, gender, diabetes, tobacco use, blood pressure and body mass index.

All subjects had no history of using cholesterol-lowering drugs.

Researchers reviewed data at four points in time prior to cancer diagnosis and found that LDL cholesterol values were lower in cancer subjects than matched controls at each point of assessment throughout an average of 18.7 years prior to diagnosis (p = .038).”

Here is another no wonder there is so much cancer nowadays.
 
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Th
I will be incorporating fertilized duck egg,

So LDL cholesterol is lower in people with cancer. @Rinse & rePeat
That is what Haidut’s study indicated.

I have been having a couple of just egg yolks twice a day, and sometimes three times. I posted this on page 7 of my egg thread, linked below, the other day….

“Frying eggs can cause the cholesterol in them to become oxidized and produce compounds known as oxysterols because of the high heat. People with heart conditions should probably use a different method for cooking eggs.”
 

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