I know this was discussed to a degree in another thread, but this study goes a bit further claiming that as being one of neurokynurenines niacin / niacinamide antagonizes the effects in the brain of both serotonin precursors and serotonin itself.
http://www.ncbi.nlm.nih.gov/pubmed/15206724
"...The following NEKY have been studied: 1-kynurenine (KYN), 3-hydroxyKYN (3HKYN), kynurenic (KYNA), anthranilic (ANT), 3-hydroxyANT (3HANT), quinolinic (QUIN), picolinic (PICA), xanthurenic (XAN), nicotinic (NIC) acids, 3-indole-pyruvate (IPA), nicotinamide (NAM). NEKY antagonize the central effects of precursors of serotonin (tryptophan and 5-HTP), and tryptamine as well."
So maybe taking some niacinamide with large meat meals would be a good method of mitigating the tryptophan damage, similar to the recommendation from Peat to eat gelatin with the meat.
http://www.ncbi.nlm.nih.gov/pubmed/15206724
"...The following NEKY have been studied: 1-kynurenine (KYN), 3-hydroxyKYN (3HKYN), kynurenic (KYNA), anthranilic (ANT), 3-hydroxyANT (3HANT), quinolinic (QUIN), picolinic (PICA), xanthurenic (XAN), nicotinic (NIC) acids, 3-indole-pyruvate (IPA), nicotinamide (NAM). NEKY antagonize the central effects of precursors of serotonin (tryptophan and 5-HTP), and tryptamine as well."
So maybe taking some niacinamide with large meat meals would be a good method of mitigating the tryptophan damage, similar to the recommendation from Peat to eat gelatin with the meat.