RichardWhite
Member
- Joined
- Nov 25, 2014
- Messages
- 22
jyb said:http://www.ncbi.nlm.nih.gov/pubmed/?term=nicotine+nonunion
Growth of new blood cells or vessels can be very ominous. Ray has written about this in the contexts of ageing, oestrogen and heavy metals.
Sorry for my delayed response here, limited Internet access and migrating to a new computer has made it difficult.
As for the topic at hand it's not something I have specifically looked into. I went to Nightlight about it (the theoretical physicist mentioned within the book), who replied with the following:
"I haven't looked before into this aspect. But going over references, the usual junk science finds better outcomes in non-smokers. But these are entirely different populations, especially in recent years under intense antismoking pressures and abuses of smokers.
Of the hard science, there are couple papers (#3 and #8) fundamental research into the effects of nicotine on the bone repair pathways and these show "biphasic" effects -- at very high dose (> 1 mmol/L) negative effect, while at 100-10,000 times lower doses (0.01-10 micromol/L; human smokers have levels well below 1 micromol/L, typically 0.1 mmol/L) there is a stimulating effect on bone healing -- see paper #8: http://www.ncbi.nlm.nih.gov/pubmed/11425648 . Similar conclusion is reached in the paper #3 (full text online): http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167453/
Of hard science, there are also 3 experimental papers on rabbits, which show negative effects, albeit using very high dose of nicotine, e.g. human quantity of 10 mg applied to rabbits which are 50-100 times lighter than humans). Obviously they tuned the experiments to the high dose/negative phase to get the desired results. There is also no real tobacco smoke (with its richer and more harmonious effects and cyclic delivery) results which suggests that those experiments went the "wrong" way.
TYPO: "(0.01-10 micromol/L; human smokers have levels well below 1 micromol/L, typically 0.1 mmol/L)"
should have the last units 0.1 mmol/L as 0.1 micromol/L. See here for dosing reference: http://www2.mrc-lmb.cam.ac.uk/groups/ws ... ta2006.pdf"