There is a lot of info on the web about alpha-tocopherol potentially competing with gamma-, beta-, and delta-tocopherols, and even depleting them when intake of alpha-tocopherol is increased. There are studies on PubMed that claim most/all anti-cancer effects vitamin E had shown in the past was due to gamma-tocopherol and not alpha-tocopherol. So, I just came upon this very recent study that tested the depletion hypothesis and came up with no evidence that alpha-tocopherol somehow antagonizes or depletes the other tocopherol isomers (and especially gamma).
http://www.ncbi.nlm.nih.gov/pubmed/23700248
So, for now it seems safe to take a supplement high in alpha-tocopherol, at least in the sense that it should be be depleting the levels of gamma-tocopherol present in your body. I personally, am alternating weekly two vitamin E suplements. One is the Sun-E 400 capsules, which is soy-free and contains only alpha-tocopherol, and on the alternate week I take the Lotioncrafter product, which is high in gamma-tocopherol. Will keep everybody posted on the results.
http://www.ncbi.nlm.nih.gov/pubmed/23700248
So, for now it seems safe to take a supplement high in alpha-tocopherol, at least in the sense that it should be be depleting the levels of gamma-tocopherol present in your body. I personally, am alternating weekly two vitamin E suplements. One is the Sun-E 400 capsules, which is soy-free and contains only alpha-tocopherol, and on the alternate week I take the Lotioncrafter product, which is high in gamma-tocopherol. Will keep everybody posted on the results.