Caffeine Protects Blood-brain Barrier From Endotoxin Damage

• Apr 21, 2014

• #1

haidut

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Ray has written that people with MS, AD, PD, etc all have increased permeability of the blood brain barrier, usually caused by endotoxin. The following studies claim that caffeine has a protective and restorative effect on the barrier function, and as such may be helpful in neurological conditions.

http://www.ncbi.nlm.nih.gov/pubmed/20541589
http://www.ncbi.nlm.nih.gov/pubmed/20164568
http://www.ncbi.nlm.nih.gov/pubmed/18387175

 

• Dec 29, 2016

• #2

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Seeweed65

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@haidut

I Can't believe this post didn't get much attention! Just thought I'd ad a couple more that I believe to be relevant to what a lot of people talk about on this forum.

Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions. - PubMed - NCBI

Progesterone protects blood-brain barrier function and improves neurological outcome following traumatic brain injury in rats. - PubMed - NCBI

Keep up the good work.

 

• Dec 29, 2016

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Waynish

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I didn't get through those studies yet, but could this be due to it stimulating peristalsis? If gut motility is increased, then endotoxin has less time to form.

 

• Jan 3, 2017
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haidut

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Seeweed65 said:

@haidut

I Can't believe this post didn't get much attention! Just thought I'd ad a couple more that I believe to be relevant to what a lot of people talk about on this forum.

Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions. - PubMed - NCBI

Progesterone protects blood-brain barrier function and improves neurological outcome following traumatic brain injury in rats. - PubMed - NCBI

Keep up the good work.

Click to expand...

Nice, thanks! I think pregnenolone and emodin also have BBB protective effects.

 

• Jan 3, 2017
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haidut

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Waynish said:

I didn't get through those studies yet, but could this be due to it stimulating peristalsis? If gut motility is increased, then endotoxin has less time to form.

Click to expand...

Could be. Caffeine is also a (functional) serotonin antagonist so that could play a role in protecting the brain too.