Serum Phospholipid Fatty Acids and Prostate Cancer Risk: Res

Edward

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I remember seeing a study from the 1970's that showed that omega-3's increased ROS (reactive oxygen species) generation in mitochondria and towards the end the authors noted that the implications of it were not understood. 40 years later the real world implications are starting to trickle through... trickle, trickle, hehe

"Inflammation may be involved in prostate cancer development and progression. This study examined the associations between inflammation-related phospholipid fatty acids and the 7-year-period prevalence of prostate cancer in a nested case-control analysis of participants, aged 55–84 years, in the Prostate Cancer Prevention Trial during 1994–2003. Cases (n = 1,658) were frequency matched to controls (n = 1,803) on age, treatment, and prostate cancer family history. Phospholipid fatty acids were extracted from serum, and concentrations of ω-3, ω-6, and trans-fatty acids (TFAs) were expressed as proportions of the total. Logistic regression models estimated odds ratios and 95% confidence intervals of associations of fatty acids with prostate cancer by grade. No fatty acids were associated with low-grade prostate cancer risk. Docosahexaenoic acid was positively associated with high-grade disease (quartile 4 vs. 1: odds ratio (OR) = 2.50, 95% confidence interval (CI): 1.34, 4.65); TFA 18:1 and TFA 18:2 were linearly and inversely associated with risk of high-grade prostate cancer (quartile 4 vs. 1: TFA 18:1, OR = 0.55, 95% CI: 0.30, 0.98; TFA 18:2, OR = 0.48, 95% CI: 0.27, 0.84). The study findings are contrary to those expected from the pro- and antiinflammatory effects of these fatty acids and suggest a greater complexity of effects of these nutrients with regard to prostate cancer risk." (Braskey et al., 2011)

"Kristal said the findings in both Fred Hutch studies were surprising because omega-3 fatty acids are believed to have a host of positive health effects based on their anti-inflammatory properties. Inflammation plays a role in the development and growth of many cancers." (Science Daily, 2013)

References
Brasky, T., Till, C., White, E., Neuhouser, M., Song, X., Goodman, P., Thompson, I., King, I., Albanes, D., & Kristal, A. (2011, January 19). Serum Phospholipid Fatty Acids and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial. American Journal of Epidemiology, 173(12), 1429-1439. doi:10.1093/aje/kwr027

Science Daily. (2013, July 13). Link Between Omega-3 Fatty Acids and Increased Prostate Cancer Risk Confirmed. Retrieved from http://goo.gl/LENLw
 

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