(Benfo)Thiamine Reduces AGEs In Vivo by 70%

Benfotiamine Inhibits Intracellular Formation of Advanced Glycation End Products in vivo

As usual we look at patentable versions of a substance to find actual results.

Such_Saturation said:

Benfotiamine Inhibits Intracellular Formation of Advanced Glycation End Products in vivo

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There has been interesting thiamine research the past few years, some discussed in this forum. Inconveniently, there has been very little comparing "clinical" benefits of benfotiamine vs other thiamine forms in the same trials, let alone combinations.

There are recent studies suggesting oral supplementing with the benfotiamine form reaches the plasma and red cells more effectively:

J Clin Pharmacol. 2014 Jun;54(6):688-95. doi: 10.1002/jcph.261. Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. Xie F1, Cheng Z, Li S, Liu X, Guo X, Yu P, Gu Z.

"Benfotiamine is a lipid-soluble thiamine precursor which can transform to thiamine in vivo and subsequently be metabolized to thiamine monophosphate (TMP) and thiamine diphosphate (TDP). This study investigated the pharmacokinetic profiles of thiamine and its phosphorylated metabolites after single- and multiple-dose administration of benfotiamine in healthy Chinese volunteers, and assessed the bioavailability of orally benfotiamine administration compared to thiamine hydrochloride.... Compared to thiamine hydrochloride, the bioavailability of thiamine in plasma and TDP in erythrocyte after oral administration of benfotiamine were 1147.3 ± 490.3% and 195.8 ± 33.8%, respectively. The absorption rate and extent of benfotiamine systemic availability of thiamine were significantly increased indicating higher bioavailability of thiamine from oral dose of benfotiamine compared to oral dose of thiamine hydrochloride."

http://www.ncbi.nlm.nih.gov/pubmed/23369791
Eur J Pharm Sci. 2013 Mar 12;48(4-5):799-802. doi: 10.1016/j.ejps.2013.01.010.
Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration. Portari GV1, Vannucchi H, Jordao AA Jr.

"The benfotiamine-treated group had its total plasma thiamine increased by 100%. In erythrocytes, thiamine levels were 4- and 25-fold higher in the groups treated with thiamine and benfotiamine, respectively, compared with the untreated groups."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083313/
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21511829/
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Benfotiamine Protects against Peritoneal and Kidney Damage in Peritoneal Dialysis. Lars P. Kihm,* Sandra Müller-Krebs,* Julia Klein,* Gregory Ehrlich,* Laura Mertes,* Marie-Luise Gross,† Antonysunil Adaikalakoteswari,‡ Paul J. Thornalley,‡ Hans-Peter Hammes,§ Peter P. Nawroth,‖ Martin Zeier,* and Vedat Schwenger*

http://www.ncbi.nlm.nih.gov/pubmed/22067901
Free Radic Biol Med. 2012 Jan 1;52(1):182-90. doi: 10.1016/j.freeradbiomed.2011.10.444. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages.
Shoeb M1, Ramana KV.

Well I question their motives since allithiamine is already lipid soluble, for example.

Such_Saturation said:

Well I question their motives since allithiamine is already lipid soluble, for example.

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You can order allithiamine from VitaminShoppe.com, and I can personally testify that it acts very quickly (faster than thiamine Hcl). You also probably need lower dosage to achieve the same plasma levels compared to thiamine Hcl. My personal experience is that 2 capsule of allithiamine (50mg each for a total of 100mg) give me the same mental and body boost as 1,500mg of thiamine Hcl. However, the latter is much cheaper and can be found in just about any store or pharmacy. Also, most studies over the last century have been done with thiamine Hcl, so it would be hard to estimate efficacy equivalence and conversion formula for dosage between thiamine Hcl and allithiamine. So, these days I just take my 1,500mg of thiamine Hcl and still get the benefits.
Just my 2c.

haidut said:

Such_Saturation said:

Well I question their motives since allithiamine is already lipid soluble, for example.

Click to expand...

You can order allithiamine from VitaminShoppe.com, and I can personally testify that it acts very quickly (faster than thiamine Hcl). You also probably need lower dosage to achieve the same plasma levels compared to thiamine Hcl. My personal experience is that 2 capsule of allithiamine (50mg each for a total of 100mg) give me the same mental and body boost as 1,500mg of thiamine Hcl. However, the latter is much cheaper and can be found in just about any store or pharmacy. Also, most studies over the last century have been done with thiamine Hcl, so it would be hard to estimate efficacy equivalence and conversion formula for dosage between thiamine Hcl and allithiamine. So, these days I just take my 1,500mg of thiamine Hcl and still get the benefits.
Just my 2c.

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Do you know whether 1500mg thiamine is hard on the kidneys? Sulbutiamine is also well respected in the nootropic world.

Such_Saturation said:

haidut said:

Such_Saturation said:

Well I question their motives since allithiamine is already lipid soluble, for example.

Click to expand...

You can order allithiamine from VitaminShoppe.com, and I can personally testify that it acts very quickly (faster than thiamine Hcl). You also probably need lower dosage to achieve the same plasma levels compared to thiamine Hcl. My personal experience is that 2 capsule of allithiamine (50mg each for a total of 100mg) give me the same mental and body boost as 1,500mg of thiamine Hcl. However, the latter is much cheaper and can be found in just about any store or pharmacy. Also, most studies over the last century have been done with thiamine Hcl, so it would be hard to estimate efficacy equivalence and conversion formula for dosage between thiamine Hcl and allithiamine. So, these days I just take my 1,500mg of thiamine Hcl and still get the benefits.
Just my 2c.

Click to expand...

Do you know whether 1500mg thiamine is hard on the kidneys? Sulbutiamine is also well respected in the nootropic world.

Click to expand...

According to this study, there no kidney side effects with 1,500mg. However, if you have information that it can be hard on the kidneys please share.

http://www.biomedcentral.com/1472-6904/12/4

Also, according to this survey, people with chronic disease experienced the highest "major improvement" with doses in the range 1,500mg - 1,800mg.

http://www.cortjohnson.org/blog/2013/07 ... -syndrome/
http://hrzone.healthrising.netdna-cdn.c ... 200931.pdf