Coffee [Cortisol, Estrogen]

Re: Coffee and estrogen and cortisol

Charlie said:

tomisonbottom said:

I'm am actually a women,

Click to expand...

the name is a joke I have with a friend of mine, lol

Click to expand...

Click to expand...

You must tell us the joke now!

Funny, I knew from the get go - I think the estrogen dominance is a bit of a giveaway!

Re: Coffee and estrogen and cortisol

tomisonbottom said:

Thank you, yeah, I did see that.
What I meant is he didn't say anything about the study showing that coffee raises estradiol.
Women who drank more than 1 cup of coffee had 70% more estradiol.

Click to expand...

Did they drink it on an empty stomach?

Re: Coffee and estrogen and cortisol

Good point about the empty stomach. It seems like that could totally change the reaction.

Re: Coffee and estrogen and cortisol

tomisonbottom said:

Does anyone know how in the world coffee can be good for us if it raises estrogen?

Click to expand...

Wiki: Caffeine is a Goitrogen
viewtopic.php?f=10&t=1494&start=10#p17742

Drinking coffee in a glycogen depleted state will elevate cortisol and estrogen because it stimulates the metabolic rate through a variety of mechanisms. Your experience of "I know for sure when I drink coffee my heart rate increases and feel anxious sometime" is a indicator that you are not glycogen replete and that there is a release of free fatty acids and that is followed by a stress response. Coffee with cream and sugar or coffee with sugar and milk or coffee with milk is usually better given your circumstances than just coffee with cream or coffee with cream and coconut oil. Coconut oil can be problematic because coconut oil stimulates ketone production which drives down blood glucose. Combined with coffee it can have a compounded effect.

The Hypoglycemic Action of Ketones. II. Evidence for a Stimulatory Feedback of Ketones on the Pancreatic Beta Cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC441933/

Further, if you are coming from a carbohydrate restricted background when you first start including fruits and sugar and milk products back in your diet glycogen tends to be used fairly quickly for a period of time. Once glycogen has refilled with sufficient and consistent eating drinking coffee has a protective effect. Most stimulants have the same effect on hormones.

Still coffee can be effective at inhibiting free fatty acids temporarily, however, if you continue to be glycogen depleted, this eventually will become a self-sustaining stress cycle.

Re: Coffee and estrogen and cortisol

I am not an expert, so if someone can refine the details/correct me that would be most useful:

In the study you mention that showed coffee increasing estradiol how was the estradiol measured? Estrogen concentration in the blood does not reflect estrogen in the tissues and I believe there is an inverse relationship between the two, so higher estrogen in the blood could mean a reduction in the tissues. You want a reduction in the tissue.

Maybe you could post a link to the study.

Re: Coffee and estrogen and cortisol

I send Ray Peat the abstract of that study showing Estradiol is increased 70% with 500 mg caffeine daily and got his response. Original study is http://www.ncbi.nlm.nih.gov/pubmed/11591405

Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use.
Lucero J, Harlow BL, Barbieri RL, Sluss P, Cramer DW.
Source
Department of Obstetrics and Gynecology, University of California at San Francisco Medical Center, San Francisco, California, USA.
Abstract
OBJECTIVE:
To examine the effects of alcohol, caffeine, and tobacco use on early follicular phase FSH, LH, E2, and sex hormone-binding globulin (SHBG).
DESIGN:
Cross-sectional study.
SETTING:
Academic medical center.
PATIENT(S):
Four hundred ninety-eight women selected from the general population, ages 36-45, who were not currently pregnant, breast feeding, or using exogenous hormones.
INTERVENTION(S):
A general questionnaire assessing demography, anthropometry, and smoking habits and a standardized dietary questionnaire assessing food and beverage frequencies, including sources of alcohol and caffeine.
MAIN OUTCOME MEASURE(S):
FSH, LH, E2, and SHBG levels measured during the early follicular phase of the menstrual cycle.
RESULT(S):
Significant associations observed in a univariate analysis included age > or =40 and current smoking associated with higher FSH; higher body mass index (BMI) associated with lower SHBG levels; and daily alcohol use, cholesterol consumption greater than the median, and coffee use >1 cup/d associated with higher E2 levels. In a multivariate model, total caffeine use was significantly associated with E2 levels after adjustment for age, BMI, total calories, current smoking, alcohol, cholesterol consumption, and day of sampling. Early follicular phase E2 increased from 28.2 pg/mL for women consuming < or =100 mg of caffeine to 45.2 pg/mL for women consuming > or =500 mg of caffeine per day, about a 70% increase.
CONCLUSION(S):
Coffee consumption and total caffeine use may increase early follicular phase E2 levels independent of related habits of alcohol or tobacco use."

Here is Ray Peat's response

"Cancer. 2009 Jun 15;115(12):2765-74. doi: 10.1002/cncr.24328.
Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women.
Kotsopoulos J, Eliassen AH, Missmer SA, Hankinson SE, Tworoger SS.
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. [email protected]
BACKGROUND:
Circulating estrogens and androgens are important factors in the development of various female cancers. Caffeine intake may decrease risk of breast and ovarian cancer, although the data are not entirely consistent. Whether or not caffeine affects cancer risk by altering sex hormone levels is currently unknown.
METHODS:
We examined the relationship of caffeine, coffee, decaffeinated coffee, and tea with plasma concentrations of estrogens, androgens, progesterone, prolactin, and sex hormone-binding globulin (SHBG) in 524 premenopausal and 713 postmenopausal women from the Nurses' Health Study (NHS) and NHSII.
RESULTS:
In premenopausal women, caffeine intake was inversely associated with luteal total and free estradiol, and positively associated with luteal progesterone levels (P-trend = .02, .01, .03, respectively). Coffee intake was significantly associated with lower luteal total and free estradiol levels, but not luteal progesterone levels (P-trend = .007, .004, .20, respectively). Among the postmenopausal women, there was a positive association between caffeine and coffee intake and SHBG levels (P-trend = .03 and .06, respectively). No significant associations were detected with the other hormones.
CONCLUSIONS:
Data from this cross-sectional study suggest that caffeine may alter circulating levels of luteal estrogens and SHBG, representing possible mechanisms by which coffee or caffeine may be associated with pre- and postmenopausal malignancies, respectively. Future studies evaluating how caffeine-mediated alterations in sex hormones and binding protein levels affect the risk of female cancers are warranted.
(c) 2009 American Cancer Society.

Nutr Cancer. 1998;30(1):21-4.
Association of coffee, green tea, and caffeine intakes with serum concentrations
of estradiol and sex hormone-binding globulin in premenopausal Japanese women.
Nagata C, Kabuto M, Shimizu H.
Department of Public Health, Gifu University School of Medicine, Japan.
[email protected]
Caffeine intake has been proposed to influence breast cancer risk. Its effect may
be mediated by hormonal changes. The relationships between caffeine-containing
beverages (coffee, green tea, black tea, oolong tea, and cola) and serum
concentrations of estradiol and sex hormone-binding globulin were evaluated in 50
premenopausal Japanese women. Intakes of caffeine and caffeine-containing
beverages were assessed by a semiquantitative food-frequency questionnaire. Blood
samples were obtained from each woman on Days 11 and 22 of her menstrual cycle.
High intakes of caffeinated coffee, green tea, and total caffeine were commonly
correlated with increasing sex hormone-binding globulin on Days 11 and 22 of the
cycle after controlling for potential confounders [Spearman correlation
coefficients (r) ranged from 0.23 to 0.31]. Green tea but not caffeinated coffee
intake was inversely correlated with estradiol on Day 11 of the cycle (r = -0.32,
p = 0.04). Although the effect of caffeine cannot be distinguished from effects
of coffee and green tea, consumption of caffeine-containing beverages appeared to
favorably alter hormone levels associated with the risk of developing breast
cancer.

Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2487-95. doi:
10.1158/1055-9965.EPI-11-0766. Epub 2011 Nov 22.
A prospective cohort study of coffee consumption and risk of endometrial cancer
over a 26-year follow-up.
Je Y, Hankinson SE, Tworoger SS, DeVivo I, Giovannucci E.
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
[email protected]
BACKGROUND: Coffee has been reported to lower levels of estrogen and insulin, two
hormones implicated in endometrial carcinogenesis, but prospective data on the
relation between coffee consumption and risk of endometrial cancer are limited.
METHODS: We prospectively assessed coffee consumption in relation to endometrial
cancer risk in the Nurses' Health Study (NHS) with 67,470 female participants
aged 34 to 59 in 1980. Cumulative average coffee intake was calculated with all
available questionnaires to assess long-term effects. Cox regression models were
used to calculate incidence rate ratios (RR), controlling for other risk factors.
RESULTS: Fewer than 4 cups of coffee per day were not associated with endometrial
cancer risk. However, women who consumed 4 or more cups of coffee had 25% lower
risk of endometrial cancer than those who consumed less than 1 cup per day
(multivariable RR = 0.75; 95% CI = 0.57-0.97; P(trend) = 0.02). We found the
similar association with caffeinated coffee consumption (RR for ≥4 vs. <1 cup/d =
0.70; 95% CI = 0.51-0.95). For decaffeinated coffee consumption, a suggestive
inverse association was found among women who consumed 2 or more cups per day
versus <1 cup/mo. Tea consumption was not associated with endometrial cancer
risk.
CONCLUSIONS: These prospective data suggest that four or more cups of coffee per
day are associated with a lower risk of endometrial cancer.
IMPACT: Drinking of coffee, given its widespread consumption, might be an
additional strategy to reduce endometrial cancer risk. However, addition of
substantial sugar and cream to coffee could offset any potential benefits.

Breast Cancer Res. 2011 May 14;13(3):R49. doi: 10.1186/bcr2879.
Coffee consumption modifies risk of estrogen-receptor negative breast cancer.
Li J, Seibold P, Chang-Claude J, Flesch-Janys D, Liu J, Czene K, Humphreys K,
Hall P.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet,
Stockholm, Sweden. [email protected]
INTRODUCTION: Breast cancer is a complex disease and may be sub-divided into
hormone-responsive (estrogen receptor (ER) positive) and non-hormone-responsive
subtypes (ER-negative). Some evidence suggests that heterogeneity exists in the
associations between coffee consumption and breast cancer risk, according to
different estrogen receptor subtypes. We assessed the association between coffee
consumption and postmenopausal breast cancer risk in a large population-based
study (2,818 cases and 3,111 controls), overall, and stratified by ER tumour
subtypes.
METHODS: Odds ratios (OR) and corresponding 95% confidence intervals (CI) were
estimated using the multivariate logistic regression models fitted to examine
breast cancer risk in a stratified case-control analysis. Heterogeneity among ER
subtypes was evaluated in a case-only analysis, by fitting binary logistic
regression models, treating ER status as a dependent variable, with coffee
consumption included as a covariate.
RESULTS: In the Swedish study, coffee consumption was associated with a modest
decrease in overall breast cancer risk in the age-adjusted model (OR> 5 cups/day
compared to OR≤ 1 cup/day: 0.80, 95% CI: 0.64, 0.99, P trend = 0.028). In the
stratified case-control analyses, a significant reduction in the risk of
ER-negative breast cancer was observed in heavy coffee drinkers (OR> 5 cups/day
compared to OR≤ 1 cup/day : 0.43, 95% CI: 0.25, 0.72, P trend = 0.0003) in a
multivariate-adjusted model. The breast cancer risk reduction associated with
higher coffee consumption was significantly higher for ER-negative compared to
ER-positive tumours (P heterogeneity (age-adjusted) = 0.004).
CONCLUSIONS: A high daily intake of coffee was found to be associated with a
statistically significant decrease in ER-negative breast cancer among
postmenopausal women.

Ann Epidemiol. 1992 May;2(3):241-7.
Pregnancy estrogens in relation to coffee and alcohol intake.
Petridou E, Katsouyanni K, Spanos E, Skalkidis Y, Panagiotopoulou K, Trichopoulos
D.
Department of Hygiene and Epidemiology, University of Athens Medical School,
Greece.
Total estrogen (TE), estradiol (E2), estriol (E3), and human placental lactogen
(hPL) levels were determined by radioimmunoassay in the blood of 141 pregnant
women during their 26th and 31st weeks of pregnancy and the results were studied
in relation to coffee and alcohol intake. After controlling for maternal age,
maternal weight at the corresponding week of pregnancy, parity, and tobacco
smoking, as well as for mutual confounding effects, coffee intake, ascertained at
the 26th week, was found to be negatively related to pregnancy E2 levels (P =
0.04 during the 26th week, and P = .16 during the 31st week), whereas alcohol
intake, also ascertained at the 26th week, was found to be positively related to
pregnancy TE levels (P = .04 during the 26th week, and P = .18 during the 31st
week). The negative relation between coffee consumption on the one hand and E2
(and possibly TE) levels on the other may be responsible for the inverse
association between maternal coffee intake and birth weight; the latter
association has been repeatedly confirmed in the literature, although it was
neither strong nor statistically significant in the present study. The relations
of maternal coffee and alcohol consumption with pregnancy estrogen levels, if
confirmed, could be utilized in studies exploring the role of prenatal exposure
to these hormones in the etiology of gonadal germ-cell tumors and possibly other
diseases.

Nutr J. 2012 Oct 19;11:86. doi: 10.1186/1475-2891-11-86.
The effects of caffeinated and decaffeinated coffee on sex hormone-binding
globulin and endogenous sex hormone levels: a randomized controlled trial.
Wedick NM, Mantzoros CS, Ding EL, Brennan AM, Rosner B, Rimm EB, Hu FB, van Dam
RM.
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave,
Boston, MA 02115, USA. [email protected]
BACKGROUND: Findings from observational studies suggest that sex hormone-binding
globulin (SHBG) and endogenous sex hormones may be mediators of the putative
relation between coffee consumption and lower risk of type 2 diabetes. The
objective of this study was to evaluate the effects of caffeinated and
decaffeinated coffee on SHBG and sex hormone levels.
FINDINGS: After a two-week run-in phase with caffeine abstention, we conducted an
8-week parallel-arm randomized controlled trial. Healthy adults (n = 42) were
recruited from the Boston community who were regular coffee consumers,
nonsmokers, and overweight. Participants were randomized to five 6-ounce cups of
caffeinated or decaffeinated instant coffee or water (control group) per day
consumed with each meal, mid-morning, and mid-afternoon. The main outcome
measures were SHBG and sex hormones [i.e., testosterone, estradiol,
dehydroepiandrosterone sulfate]. No significant differences were found between
treatment groups for any of the studied outcomes at week 8. At 4 weeks,
decaffeinated coffee was associated with a borderline significant increase in
SHBG in women, but not in men. At week 4, we also observed several differences in
hormone concentrations between the treatment groups. Among men, consumption of
caffeinated coffee increased total testosterone and decreased total and free
estradiol. Among women, decaffeinated coffee decreased total and free
testosterone and caffeinated coffee decreased total testosterone.
CONCLUSIONS: Our data do not indicate a consistent effect of caffeinated coffee
consumption on SHBG in men or women, however results should be interpreted with
caution given the small sample size. This is the first randomized trial
investigating the effects of caffeinated and decaffeinated coffee on SHBG and sex
hormones and our findings necessitate further examination in a larger
intervention trial."

Re: Coffee and estrogen and cortisol

GELATIN put inside of your coffee, with cream and sugar or honey, a far amount of the gelatin- and then eat your eggs and Oj, with salt,
On the above -- intake of food you will not see your heart rate increase or have any side affects from coffee but positive ones.

Re: Coffee and estrogen and cortisol

Or just smoke a couple cigarettes:

Kadohama, N., Shintani, K., & Osawa, Y. (1993). Tobacco alkaloid derivatives as inhibitors of breast cancer aromatase. Cancer letters, 75(3), 175–82. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8313352

Osawa, Y., Tochigi, B., Tochigi, M., Ohnishi, S., Watanabe, Y., Bullion, K., … Yarborough, C. (1990). Aromatase inhibitors in cigarette smoke, tobacco leaves and other plants. Journal of enzyme inhibition, 4(2), 187–200. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2098524

Coffee and estrogen and cortisol

NIH study

American Society of Reproductive Medicine study

Coffee and estrogen and cortisol

Beebop said:

I am not an expert, so if someone can refine the details/correct me that would be most useful:

In the study you mention that showed coffee increasing estradiol how was the estradiol measured? Estrogen concentration in the blood does not reflect estrogen in the tissues and I believe there is an inverse relationship between the two, so higher estrogen in the blood could mean a reduction in the tissues. You want a reduction in the tissue.

Maybe you could post a link to the study.

Click to expand...

This is usually what I think when people start discussing estrogen levels. When they measure post-menopausal women they have low estrogen. They actually have a high tissue estrogen and low progesterone. Progesterone knocks estrogen out of the tissue and into the blood, where it can then be potentially eliminated. There seems to be some connection between coffee and progesterone so if drinking coffee is raising blood estrogen levels maybe the coffee is acting like progesterone to help eliminate estrogen from inside the tissue.

They need to do these coffee studies and measure blood estrogen as well as take biopsies to measure the tissue, but then they would have to admit that there is a difference between tissue and blood estrogen and their whole charade about estrogen dropping with age will come to an end.

Coffee and estrogen and cortisol

tomisonbottom said:

https://raypeatforum.com/forums/posts/17617/ Hello,


Does anyone know how in the world coffee can be good for us if it raises estrogen?
I read his article about coffee and the health benefits but he doesn't say anything about how it effect estrogen.

Thanks so much

Click to expand...

Coffee only raises the stress hormones if there isn't adequate sugar and/or protein in the diet. Many people drink coffee on an empty stomach (or mostly empty). But coffee raises the metabolism no matter what you've eaten, and if you have low blood sugar it raises your cortisol to make sugar out of your own body, or adrenaline if you haven't enough protein. So if you eat enough sugar and protein before and during coffee consumption, the stress hormones do not rise and the health benefits of coffee are realized through increased metabolic rate.

Coffee and estrogen and cortisol

Edward said:

Or just smoke a couple cigarettes:

Kadohama, N., Shintani, K., & Osawa, Y. (1993). Tobacco alkaloid derivatives as inhibitors of breast cancer aromatase. Cancer letters, 75(3), 175–82. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8313352

Osawa, Y., Tochigi, B., Tochigi, M., Ohnishi, S., Watanabe, Y., Bullion, K., … Yarborough, C. (1990). Aromatase inhibitors in cigarette smoke, tobacco leaves and other plants. Journal of enzyme inhibition, 4(2), 187–200. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2098524

Click to expand...

Well this is interesting. I've always known cigarettes were highly androgenic. Too bad for the CO which is terrible for your cardiovascular system.

Edward said:

Drinking coffee in a glycogen depleted state will elevate cortisol and estrogen because it stimulates the metabolic rate through a variety of mechanisms. Your experience of "I know for sure when I drink coffee my heart rate increases and feel anxious sometime" is a indicator that you are not glycogen replete and that there is a release of free fatty acids and that is followed by a stress response. Coffee with cream and sugar or coffee with sugar and milk or coffee with milk is usually better given your circumstances than just coffee with cream or coffee with cream and coconut oil. Coconut oil can be problematic because coconut oil stimulates ketone production which drives down blood glucose. Combined with coffee it can have a compounded effect.

Click to expand...

I definitely notice cortisol and estrogen increasing from coffee. I have some sort of liver disfunction I believe though. The annoying thing its a catch 22 because apparantly coffee can improve the health of the liver, but not if your liver is unhealthy!