Ray has written about the connections between serotonin and migraine, but AFAIK he did not name a direct causative agent. This study claims that serotonin causes release of nitric oxide in the meningeal area of the brain and spinal cord and that is the cause of migraine.
http://onlinelibrary.wiley.com/doi/10.1 ... ated=false
The study also implicates a specific serotonin "receptor" where serotonin exerts its action and causes release of NO. The "receptor" is 5-HT2B. A very potent antagonist at that (and others) receptor is cyproheptadine, and not surprisingly there are a number of studies showing that cyproheptadine does indeed reduce migraine symptoms.
http://www.ncbi.nlm.nih.gov/pubmed/24255866
Finally, if NO is the direct cause of migraine then agents that reduce NO production should be helpful as well. Two of the better known ones are niacinamide and vitamin B12. I think aspirin has some anti-NO action as well.
http://onlinelibrary.wiley.com/doi/10.1 ... ated=false
The study also implicates a specific serotonin "receptor" where serotonin exerts its action and causes release of NO. The "receptor" is 5-HT2B. A very potent antagonist at that (and others) receptor is cyproheptadine, and not surprisingly there are a number of studies showing that cyproheptadine does indeed reduce migraine symptoms.
http://www.ncbi.nlm.nih.gov/pubmed/24255866
Finally, if NO is the direct cause of migraine then agents that reduce NO production should be helpful as well. Two of the better known ones are niacinamide and vitamin B12. I think aspirin has some anti-NO action as well.