Low Sodium And Dementia

Blossom

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I see that a lot. It's tragic that medicine persists with the low sodium diets. I've wondered how many elderly people could make a more complete recovery if sodium wasn't so misunderstood. Great link s_s.
 
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Look at how solid Ray Peat's view is when attacked from all sides. I don't think there is a single experiment or statistical confidence interval which can even come close to the rationality we have attained in our minds by looking at the organism in this manner.

In this respect, the high urine sodium concentration seems to be due to urine sodium wasting and not to volume expansion. Although the exact mechanism of natriuresis is unknown, it has been suggested that a brain natriuretic peptide (atrial natriuretic peptide and endogenous ouabain have also been incriminated44) is released and causes an increase in sodium excretion and in urine volume.11,38 The natriuretic factor has been identified as a protein and has been partially characterized.44,45 Work is underway to isolate and identify this natriuretic factor. A natriuretic factor with characteristics similar to those observed in patients with intracranial disease has been reported in patients with Alzheimer's disease.45

The changes in uric acid homeostasis are particularly useful in differentiating between SIADH and cerebral salt-wasting syndrome.28,44 Uric acid levels are depressed in patients with SIADH,19,25,26,27 whereas in volume-depleted patients with hyponatremia uric acid levels are normal or slightly increased in the presence of intact renal tubular function.44 However, uric acid levels are depressed when there is renal salt wasting. In fact, serum uric acid levels in cerebral salt-wasting syndrome tend to be unexpectedly low owing to a tubular transport abnormality for uric acid.38,44 Thus, hypouricemia and high urine levels of uric acid may be common features of intracranial disease in general.44,46 Hypouricemia and increased renal uric acid excretion have been noted in patients with Alzheimer's disease even in the absence of hyponatremia.38,43,47 There is also evidence that hypouricemia and hyponatremia coexist in patients with AIDS.
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC100882/#r45-23]

[http://www.ncbi.nlm.nih.gov/pubmed/8486882]

Alzheimer's medication causing hyponatremia [http://www.researchgate.net/publication/51488346_Rivastigmine_associated_hyponatremia_in_an_older_patient_with_Alzheimer's_disease]
 

Blossom

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[highlight=#ff80bf]Ray Peat right again![/highlight]
 

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