Such_Saturation
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- Nov 26, 2013
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Ray Peat has grouped Parkinson's disease with other effects of insufficient energy and calcium hyperexcitation. It can bee seen that lithium selects for healthier mitochondria: [http://www.raypeatforum.com/forum/viewtopic.php?f=36&t=4169&p=50330].
Lithium has many commonalities with sodium.
Lithium - a new weapon in the fight against Parkinson's?
Investigating the Mechanism of Lithium Treatment of a Parkinson’s Disease Model with SRF Intern Sean Batir
Malignant syndrome in Parkinson's disease without dopaminergic drug withdrawal
Bipolar disorder is treated with lithium and has associations with Parkinson's disease. [http://www.ncbi.nlm.nih.gov/pubmed/12548347]
Bipolar Disorder And Gene Abnormalities: Sodium, Calcium Imbalances Linked To Manic Depressive Episodes
[Calcium antagonists and lithium in preventive treatment of manic-depressive disorder].
Hyponatremia-induced change in mood mimicking late-onset bipolar disorder.
So we have, according to Ling's Association-Induction "hypothesis", that chronic hyperexcitation deranges the seesaw of sodium and calcium, depleting energy in the process.
Sodium Influx Plays a Major Role in the Membrane Depolarization Induced by Oxygen and Glucose Deprivation in Rat Striatal Spiny Neurons
When the mitochondria work well, they order the water around them, keeping the nerve polarized and bringing themselves where their field is most needed.
Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
A high density of Na+ channels and Na+/K+ ATPases at the nodes of Ranvier is essential for myelinated axons to conduct high-velocity nerve impulses and to permit repetitive firing. Thus, regions near nodes of Ranvier have a high energy demand.
Owing to the complex geometry of neurons, specialized mechanisms are required to transport mitochondria to their destinations and to ensure that mitochondria remain stationary in regions with a high demand for energy production and Ca2+ homeostatic capacity.
Lithium has many commonalities with sodium.
Lithium - a new weapon in the fight against Parkinson's?
Investigating the Mechanism of Lithium Treatment of a Parkinson’s Disease Model with SRF Intern Sean Batir
Malignant syndrome in Parkinson's disease without dopaminergic drug withdrawal
Bipolar disorder is treated with lithium and has associations with Parkinson's disease. [http://www.ncbi.nlm.nih.gov/pubmed/12548347]
Bipolar Disorder And Gene Abnormalities: Sodium, Calcium Imbalances Linked To Manic Depressive Episodes
[Calcium antagonists and lithium in preventive treatment of manic-depressive disorder].
Hyponatremia-induced change in mood mimicking late-onset bipolar disorder.
So we have, according to Ling's Association-Induction "hypothesis", that chronic hyperexcitation deranges the seesaw of sodium and calcium, depleting energy in the process.
Sodium Influx Plays a Major Role in the Membrane Depolarization Induced by Oxygen and Glucose Deprivation in Rat Striatal Spiny Neurons
When the mitochondria work well, they order the water around them, keeping the nerve polarized and bringing themselves where their field is most needed.
Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
A high density of Na+ channels and Na+/K+ ATPases at the nodes of Ranvier is essential for myelinated axons to conduct high-velocity nerve impulses and to permit repetitive firing. Thus, regions near nodes of Ranvier have a high energy demand.
Owing to the complex geometry of neurons, specialized mechanisms are required to transport mitochondria to their destinations and to ensure that mitochondria remain stationary in regions with a high demand for energy production and Ca2+ homeostatic capacity.
