Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

Even in the absence of weight gain, fructose rapidly causes liver damage that we suggest is secondary to endotoxemia and MT. HS relates to the duration of fructose consumption and total calories consumed. These data support fructose inducing both MT and ectopic fat deposition in primates.

http://ajcn.nutrition.org/content/early ... 2d1ee6fa97

Always good to also look at studies not supporting Ray Peat's view. What do you guys think of this study ?

"One diet used was very high in fructose (;25% of calories), whereas both the high-fructose and the control diets were relatively low in fat (17% and 13%, respectively). It should be noted that the sources of fat in the diets of the 2 groups were highly disparate (vegetable oils and butter com- pared with pork fat) and the sources of protein were completely different. The calories per kilogram of body weight provided to the NHPs also differed by .10%. Thus, conclusions must be drawn carefully from 2 very different diets not solely differing in the source of carbohydrate. In the Kavanagh et al study, 17 monkeys fed a high-fructose diet for 3 mo to 7 y had succumbed to non–diet-related issues and their livers became available for histologic examination. Similarly, 10 control monkeys fed the standard primate diet also had livers available for evaluation. The outcomes must be viewed with some caution because the fructose-fed monkeys were significantly older than the controls
(middle-aged compared with elderly), and they weighed signif- icantly more as well. Thus, the findings related to diabetes cannot yet be accepted because both weight and age strongly influence the onset of type 2 diabetes in both humans and monkeys"

So they fed monkeys a relatively high fat diet for a monkey of vegetable oil, butter and pork fat. Three things that should be entirely absent in a monkeys diet, then gave them huge amounts of pure fructose. Also the tested monkeys had worse health and were older than the control group.

Hmm...