Ebola Transmitted via Infectious Aerosol Particles

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charlie

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LucyL

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Yeah,
Filoviruses, which are classified as Category
A Bioterrorism Agents by the Centers for Disease Control and Prevention (Atlanta, GA), have stability
in aerosol form comparable to other lipid containing viruses such as influenza A virus, a low infectious
dose (<10 pfu) by the aerosol route in NHPs, and case fatality rates as high as ~90% ( [6–8]).
from http://www.mdpi.com/1999-4915/4/10/2115/pdf

Warm, humid climates don't experience flu outbreaks either like we do in the US, Europe and northern parts of the northern hemisphere. Dry, cold air is the best for aerosolization...
 

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LucyL said:
Yeah,
Filoviruses, which are classified as Category
A Bioterrorism Agents by the Centers for Disease Control and Prevention (Atlanta, GA), have stability
in aerosol form comparable to other lipid containing viruses such as influenza A virus, a low infectious
dose (<10 pfu) by the aerosol route in NHPs, and case fatality rates as high as ~90% ( [6–8]).
from http://www.mdpi.com/1999-4915/4/10/2115/pdf

Warm, humid climates don't experience flu outbreaks either like we do in the US, Europe and northern parts of the northern hemisphere. Dry, cold air is the best for aerosolization...
I have a N95 particulate respirator but it states on the box - "95% efficiency against solid and liquid aerosols that DO NOT CONTAIN OIL." Sounds like that wouldn't work for Ebola.
:cry:
 
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http://www.ncbi.nlm.nih.gov/pubmed/10881895 The abstract, in full: Quote:

Lancet. 2000 Jun 24;355(9222):2210-5.

Human asymptomatic Ebola infection and strong inflammatory response.

Leroy EM1, Baize S, Volchkov VE, Fisher-Hoch SP, Georges-Courbot MC, Lansoud-Soukate J, Capron M, Debré P, McCormick JB, Georges AJ.
Author information

Abstract
BACKGROUND:

Ebola virus is one of the most virulent pathogens, killing a very high proportion of patients within 5-7 days. Two outbreaks of fulminating haemorrhagic fever occurred in northern Gabon in 1996, with a 70% case-fatality rate. During both outbreaks we identified some individuals in direct contact with sick patients who never developed symptoms. We aimed to determine whether these individuals were indeed infected with Ebola virus, and how they maintained asymptomatic status.

METHODS:

Blood was collected from 24 close contacts of symptomatic patients. These asymptomatic individuals were sampled 2, 3, or 4 times during a 1-month period after the first exposure to symptomatic patients. Serum samples were analysed for the presence of Ebola antigens, virus-specific IgM and IgG (by ELISA and western blot), and different cytokines and chemokines. RNA was extracted from peripheral blood mononuclear cells, and reverse transcriptase-PCR assays were done to amplify RNA of Ebola virus. PCR products were then sequenced.

FINDINGS:

11 of 24 asymptomatic individuals developed both IgM and IgG responses to Ebola antigens, indicating viral infection. Western-blot analysis showed that IgG responses were directed to nucleoprotein and viral protein of 40 kDa. The glycoprotein and viral protein of 24 kDa genes showed no nucleotide differences between symptomatic and asymptomatic individuals. Asymptomatic individuals had a strong inflammatory response characterised by high circulating concentrations of cytokines and chemokines.

INTERPRETATION:

This study showed that asymptomatic, replicative Ebola infection can and does occur in human beings. The lack of genetic differences between symptomatic and asymptomatic individuals suggest that asymptomatic Ebola infection did not result from viral mutations. Elucidation of the factors related to the genesis of the strong inflammatory response occurring early during the infectious process in these asymptomatic individuals could increase our understanding of the disease.
 
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Dallas Officials Looking For Missing "Low Risk" Potential Ebola Patient As CDC 'Almost' Admit Ebola Is Airborne

Frieden said:
"There are certainly theoretical situations where someone sneezes... and you touch your eyes or mouth or nose," and catch the virus from any transmitted particles, he said. "[But] realistically you can say what may be theoretically possible as opposed to what actually happens in the real world," he added.

http://www.zerohedge.com/news/2014-10-0 ... bola-airbo
 
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How exactly does that differ from the flu? <<Typically, influenza is transmitted through the air by coughs or sneezes, creating aerosols containing the virus.>>
 
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Such_Saturation said:
How exactly does that differ from the flu? <<Typically, influenza is transmitted through the air by coughs or sneezes, creating aerosols containing the virus.>>

The difference (if there was one) would be in the stability of the virus in aerosol form. Studies indicate though that EVD is fairly stable, on par with influenza. But even the flu virus isn't very stable in warm, humid equatorial climates.
 
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So the nurse who treated a patient IN EUROPE got it from him. Clearly inadequate protocols.
 
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...

She is a woman of 44, married and childless, of Galician origin but has been in the Carlos III over 15 years, according to other health center that consulted by this newspaper. These other colleagues who, as the affected, have been working in shifts to care of the missionaries, have expressed surprise at the spread as protective measures were "extreme". Health protection wearing two pairs of gloves and goggles when treated patients.

http://elpais.com/elpais/2014/10/06/cie ... 52524.html
 

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That "extremew" protection doesnt sound very effective. Some sort of respiratory mask should be used also. Sounds like that wasn't the case en espana.
 
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Yea, and rinse the mask with disinfectant and throw away filters after one use. I don't know how feasible it is without self contained breathing apparatus.
 
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Charlie said:
Some Ebola experts worry virus may spread more easily than assumed

http://www.latimes.com/nation/la-na-ebo ... tml#page=1
A person could develop a fever mid flight. Checking temps beforehand is no guarantee. I wish they would stop with the foolish games. I guess when it reaches epidemic proportions something might change.
 
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Blossom said:
Charlie said:
Some Ebola experts worry virus may spread more easily than assumed

http://www.latimes.com/nation/la-na-ebo ... tml#page=1
A person could develop a fever mid flight. Checking temps beforehand is no guarantee. I wish they would stop with the foolish games. I guess when it reaches epidemic proportions something might change.

I'll bet money that our doctors would let 101.4 degrees aboard for being "in range".
 
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Rand Paul to CNN: 'I don't want to create panic' over Ebola

"The administration has been saying over and over again, 'Oh, this is only transmitted through direct bodily fluids.' They make you think that this is like AIDS and not very contagious. And then in the next statement, they very quietly say, 'Oh, but if you're within three feet of someone, we call that direct contact.' Well I don't think Americans think standing within three feet of someone is direct contact," he said.

"They also say it can't be aerosolized," Paul said Friday. "But the question people should be asking is, 'Can it be transmitted by someone coughing on you?' I think the virus can be suspended in cough particles. They call that direct contact. But I think most Americans would think that's being aerosolized."

http://us.cnn.com/2014/10/10/politics/r ... index.html
 
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The ebola fits perfectly in the cycles of epidemic. The high point in this should be 2019
 

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