niacinamide

  1. haidut

    Chronic pain due to mitochondrial dysfunction, niacinamide can treat it

    As many of my readers know, there is an epidemic of chronic pain disorders in Western countries, which has subsequently led to over-prescription and (ab)use of opioid medication, which has then acted as a gateway drug and fueled a massive and deadly opioid epidemic in those countries. In order...
    • haidut
    • Thread
    • inflammation mitochondria niacinamide nicotinamide nicotinamide riboside pain vitamin b3
    • Replies: 0
    • Forum: Scientific Studies
  2. haidut

    HUMAN STUDY: Vitamin B3 ups muscle/bone mass/strength, lowers fat, improves glucose control

    The study is epidemiological and it did not distinguish between the various forms of vitamin B3 available through the diet or supplements. However, it was well-controlled and its findings match the known biochemical effects of vitamin B3, which the study authors cite themselves as the likely...
    • haidut
    • Thread
    • diabetes fat insulin muscle niacin niacinamide nicotinamide sarcopenia vitamin b3
    • Replies: 13
    • Forum: Scientific Studies
  3. haidut

    HIV-1 Breakthrough: niacinamide as a possible treatment

    The study does not claim a cure but it is a direct corroboration of human trials with HIV-1 patients conducted back in the early 1990, as those trials used high dose niacinamide (3g daily) and found improvement in the general condition of the patients. The mechanism of actions was, again...
    • haidut
    • Thread
    • aids hiv hiv-1 nad niacinamide nicotinamide nmn vitamin b3
    • Replies: 1
    • Forum: Scientific Studies
  4. haidut

    Niacinamide may treat Parkinson Disease (PD)

    A very interesting study, which used a relatively high dose of nicotinamide riboside (NR) to treat Parkinson Disease (PD). The dosage used was 3,000mg daily for 4 weeks and it resulted in improvement of motor and cognitive symptoms of PD, while producing no side effects. The study references...
    • haidut
    • Thread
    • metabolism nad nad/nadh niacinamide nicotinamide riboside oxphos parkinson vitamin b3
    • Replies: 9
    • Forum: Scientific Studies
  5. teds

    Niacinamide/Tallow- maths assistance please!

    Hello all. Wanting to make some body cream with tallow. I saw another thread around this and someone added Niacinamide and other bits. Can someone help with dosage for the Niacinamide? If I have half a cup of tallow- how much Niacinamide should I add for benefit? Slight random but thanks for...
  6. haidut

    Niacinamide may lower blood pressure in humans by raising NAD+

    The study actually used the now-banned NAD+ precursor known as nicotinamide mononucleotide (NMN), but, as I keep reminding people, multiple studies have demonstrated statistically equivalent rise in NAD+ levels from equal doses of any of the known NAD+ precursors such as niacin, niacinamide...
    • haidut
    • Thread
    • cd38 cvd hypertension inflammation niacinamide nicotinamide nicotinamide mononucleotide vitamin b3
    • Replies: 9
    • Forum: Scientific Studies
  7. Soren

    Late stage brain cancer any advice?

    Hi all. A friend of mine has late stage brain cancer. He has been very reluctant up to this point to try any alternative therapies and is on a very large dose of morphine constantly for the pain. The last thing he has been on is some form of genome therapy but has been told that it won´t do...
    • Soren
    • Thread
    • aspirin brain cancer bvitamins cancer cyproheotadine dhea niacinamide progesterone
    • Replies: 26
    • Forum: Cancer
  8. webbt

    Super Dosing Niacin -- A Half Cup and More

    What justifies you doing this? Extensive knowledge about nutraceuticals. Chronic debilitating problems with health. Unable to seek professional help due to life circumstances. Risk minimized by careful planning and consideration. There have been reports of 100 grams of niacin consumed at...
  9. haidut

    Human trial - niacinamide may treat Alzheimer Disease (AD)

    One of my first posts on the topic of bioenergetics - more than a decade ago - was in regards to a promising animal study with the human-equivalent dose (HED) of 30mg/kg niacinamide (NAM) daily showing robust effects on that animal species' model of AD. The authors of the animal study followed...
    • haidut
    • Thread
    • alzheimer dementia nad niacinamide nicotinamide oxphos
    • Replies: 8
    • Forum: Scientific Studies
  10. I

    Hamsters with niacin/vitamin b3 deficiency cannibalize their young

    https://royalsocietypublishing.org/doi/10.1098/rspb.2016.2168 "This study shows that maize-based diets cause high rates of maternal infanticides in the European hamster, a farmland species on the verge of extinction in Western Europe. Vitamin B3 supplementation is shown to effectively restore...
    • imcoconut
    • Thread
    • hamster niacin niacinamide scientific study study vitamin b3 vitamin deficiency
    • Replies: 9
    • Forum: Scientific Studies
  11. J

    Niacinamide headache cured with magnesium

    Just wanted to make a quick post if anyone having issues with high dose niacinamide and headache. Felt really terrible yesterday and today I took smaller doses but could feel the headache creeping back. I thought it might be a methylation issue so I took it with some TMG which did not help, then...
    • Jonk
    • Thread
    • headache niacinamide thiamine tmg
    • Replies: 2
    • Forum: Testimonials
  12. haidut

    NAD+ deficiency causes kidney disease, niacinamide prevents it

    Chronic kidney disease (CKD) is one of the most prevalent complications of obesity and diabetes. Its causes, as usual, are "unknown" according to mainstream medicine but high glucose levels and genetic predisposition are thought to play a role. Many studies have called into question these...
  13. haidut

    Niacinamide may prevent neurodegeneration

    Yet another study demonstrating that maintaining high energy levels through OXPHOS is crucial for health, in this case brain health. There are many studies, going back decades, demonstrating that a drop in NAD+ levels, and thus of NAD/NADH and, consequently, of OXPHOS is a common feature of...
    • haidut
    • Thread
    • autophagy nad neurodegeneration niacinamide nicotinamide parp sirtuin vitamin b3
    • Replies: 6
    • Forum: Scientific Studies
  14. haidut

    Vitamin B3 counteracts (cancer) cachexia, by restoring NAD+ levels

    As many of my readers know, the majority of cancer patients do not succumb from the actual tumor burden, but as a result of (usually in that order) cachexia, immunocompromise from radiation/chemotherapy, hospital-acquired infection, and/or cytokine storm after surgery for removing the tumor. Of...
    • haidut
    • Thread
    • autophagy cachexia cancer nad niacin niacinamide vitamin b3
    • Replies: 11
    • Forum: Scientific Studies
  15. haidut

    Niacinamide/NAD+ may prevent heart failure

    The rates of cardiovascular disease (CVD) continue to rise and the condition is still the top killer in developed countries, though it is likely that cancer will take the top spot in the next few years and CVD will move back to second place. Heart failure (HF) is one of the common outcomes of...
    • haidut
    • Thread
    • fibrosis heart failure nad niacinamide nicotinamide oxphos
    • Replies: 0
    • Forum: Scientific Studies
  16. haidut

    Niacinamide fully reverses endotoxemia and leaky gut (from ethanol)

    The study below is a true gem due to both its broadness of impact, as well as the ease and low-cost of the therapeutic intervention it studied. Chronic endotoxemia, a cause and a result of increased gut permeability (aka "leaky gut") is now known to be a major cause of virtually all chronic...
    • haidut
    • Thread
    • alcohol atp endotoxin ethanol leaky gut lps nad niacinamide nicotinamide
    • Replies: 21
    • Forum: Scientific Studies
  17. I

    Niacinamide - Bloat/Water Retention

    Hello Niacinamide at any dose (from 50mg to the full 500mg capsule) increases water retention/oedema. I am on Rx levothyroxine sodium 100mcg. I keep a tight dietary schedule with 180-200g protein, 540-560g carbs, and 40-45g fat and I powerlift 4x days/week. My body-fat percentage is around...
  18. FitnessMike

    Share your b3 experiences/side effects with me and the world

    Pros: 1) I find that it have notripic effec, my brain works better, feel smarter and memory is better. 2) It was one of the missing links for my meds to exert effect i believe, pulse went up since i staerted playing wiht niacinamine. Cons: 1) insomnia onset, need to work it out , didint have...
  19. FitnessMike

    Can you saturate your body with b vitamins? specifically b3?

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  20. haidut

    A single, low dose niacinamide drops triglycerides by 75%

    Among the vitamin B3 analogs, niacin is perhaps the most famous for its ability to both raise "good" cholesterol (HDL) and also lower triglycerides. However, niacinamide, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are all effective precursors to NAD (as niacin is) and...
    • haidut
    • Thread
    • lipolysis nad niacinamide nicotinamide nmn triglycerides vitamin b3
    • Replies: 17
    • Forum: Scientific Studies
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