pregnenolone

  1. Mauritio

    A mild Vitamin A deficiency decreases DHEA and Pregnenolone formation by about 40%

    Even a mild Vitamin A deficiency decreases DHEA and Pregnenolone formation by about 40% in rats. Not surpsing, since Vitamin A is needed for the enzyme that converts cholesterol into pregnenolone ( Vitamin A deficiency impairs gonadal steroid synthesis) Even more evident was the effect on...
  2. M

    Can Magnesium Raise Pregnenolone & Dhea Levels?

    Curious if this would help. Since adrenals are all connected? My pregnenolone levels came in lower AFTER supplementing 50 mgs of pregnenolone. My levels were at 85 now at 50. Also, I notice my vitamin D levels climb very slowly even after 10,000iu daily with K combination. So maybe my focus...
  3. D

    How can Pregnenolone cause Hair loss?

    Ive seen several people in this forum saying that pregnenolone causes them to lose hair. Charlie says so as well. Shouldn't increased metabolism reduce or even reverse hair loss? And shouldn't pregnenolone fix the hormone imbalance many claim is the cause of hair loss? I don't understand this.
  4. F

    RPF approved/peaty "PCT" protocol for testosterone base cycle?

    I've decided I want to run testosterone base indefinitely for muscle building and libido purposes, but want to be careful that I have a way to recover my natural hormone production after cycle. I've run a steroid cycle before a few years back, and hoped to use SERMs to recover, as is...
    • feedandseed
    • Thread
    • bodybuilding estrogen antagonist pct pregnenolone progesterone steroid steroidogenesis testosterone
    • Replies: 4
    • Forum: Hormones
  5. TruffleGnocchi

    DHEA levels in young children? And how to prevent it's conversion?

    There are papers talking about DHEA decline and supplementation could resolve a lot of problems related to aging. I see some sources say DHEA levels are low or significantly lower in childhood than in teens or young adults. Is this really the hormone of such importance if this is true? When I...
    • TruffleGnocchi
    • Thread
    • aging anti-aging cortisol dhea growth hormone pregnenolone youth
    • Replies: 3
    • Forum: DHEA
  6. haidut

    Progesterone (or pregnenolone) - a cheap, safe and effective treatment of infertility

    It looks like Big Pharma is getting desperate and are now setting their sights on progesterone. The studies showing benefits of bioidentical progesterone have been steadily increasing over the last 5+ years and it probably won't be long before a pharma company asks the FDA to declare...
    • haidut
    • Thread
    • conception female infertility male miscarriage pregnenolone progesterone
    • Replies: 4
    • Forum: Scientific Studies
  7. :M :B.

    Purifying pregnenolone with isopropyl alcohol

    Haidut mentioned how to purify pregnenolone here at about the 1hr 12min mark. https://dannyroddy.substack.com/p/generative-energy-101-fasting-promotes?utm_source=post-email-title&publication_id=411312&post_id=125802002&isFreemail=true&utm_medium=email I messed up trying to do this and you don't...
  8. Charlieb91

    Pregnenolone concerns

    I have a bottle of source naturals 10mg pregnenolone in my kitchen cupboard. I want to try it for androgenic/ergogenic effects but I’m concerned it may cause problems as it seems pregnenolone is unpredictable on how people respond hormonally. If I take it and respond bad will discontinuing...
  9. Mauritio

    Pregnenolone reduces alcohol cravings in humans

    This study showed that giving people 300 or 500mg of Pregnenolone reduced cravings in alcoholics and also normalized their stress parameters like cortisol and ACTH. I cant get the full text, but the abstract only mentions the 300mg dose as effective, so I'm not sure about the 500mg dose. But...
  10. Mauritio

    Pregnenolone protects heart from chemotherapy drug

    If somebody decides to take doxorubicin or another chemotherapy drug for whatever reason, then it seems smart to take pregnenolone with it. Doxorubicin is known for having a lot of side effects on the heart : "The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence...
  11. Mauritio

    Shift workers have lower Testosterone and Pregnenolone

    "Lower levels of serum pregnenolone and total testosterone were found in the shift workers compared to the daytime workers. Variations in pregnenolone levels may have consequences for well-being, and they might produce consequences for the levels of hormones downstream of the steroid hormone...
  12. Mauritio

    Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease

    In this study they showed that administering pregnenolone to rats with parkinsons ameliorated the dyskinesia, caused by L-DOPA. The Human equivalent dosages were 75mg, 225mg and 450mg per day. There was a dose-response effect, meaning higher dose = more effective. Now they often get the MoA...
    • Mauritio
    • Thread
    • dopamine dyskinesia parkinson's parkinson's disease pregnenolone
    • Replies: 0
    • Forum: Scientific Studies
  13. youngsinatra

    Pregnenolone Stops Bile Production? (A Hint To Constipation?)

    I am curious about the effects of supplemental pregnolone on the liver/gallbladder and biliary secretion/excretion, because I noticed signs of poor bile output after a week of using it, esp. poorer fat absorption (slight malabsorption) and constipation. Because of my long-term struggle with a...
  14. Connor888

    Capsule absorption?

    I have been supplementing with basic substances for awhile, and some pregnenolone now and again -- without much benefit to speak of really. Out of curiosity, I decided to try a tiny amount of the powder from a b complex & pregnenolone on my tongue. And I have never felt better; despite taking...
  15. ChetnikPeater

    Making a Homemade Transdermal

    Hello Everyone. I have recently gained an interest in making homemade supplements, and have difficulty finding any type of recipe for DMSO containing supplements (like haidut's former ones). DMSO is the most superior solvent and would like more information on the % of DMSO, your steroid or...
  16. M

    Does DHEA or Pregnenolone cause hairloss?

    Is there correlation between hair loss while taking these two together? i am taking thyroid but usually that would help the situation. Maybe because it’s fairly new to my body (3 months) Hair is dry. Falls out whenever i touch it or run my fingers through. BUT its weird my hair...
  17. EnergeticLeo

    Why is Progest-E trusted but there is no consensus on a good pregnenolone?

    From what I understand Peat had stopped recommending pregnenolone because of poor reactions he was hearing, and suspected the quality of pregnenolone had declined. But progest-E's progesterone is USP and AFAIK he was still recommending and using progest-E in recent years. Does anyone know where...
  18. haidut

    Cells preferentially accumulate Pregnenolone (P5), Progesterone (P4), and DHEA

    A study not directly dealing with disease, though its findings are probably relevant for all diseases. It demonstrates that in addition to the so-called "active transport", which we have been told is the dominant mechanism in steroid absorption and intracellular relevance, there also exists a...
    • haidut
    • Thread
    • androgens cortisol dhea estrogen intracellular p4 p5 pregnenolone progesterone uptake
    • Replies: 3
    • Forum: Scientific Studies
  19. haidut

    Pregnenolone (P5) blocks stress-induced anxiety, hypertension and cocaine cravings

    A great new study, and with humans too! As the study aptly demonstrates, the primary driver of cocaine cravings is likely stress and the anxiety it causes. This finding is another corroboration of the findings of the great Rat Park experiment/study on "addiction". In the study below, the...
    • haidut
    • Thread
    • addiction anxiety cocaine cvd hypertension p5 pregnenolone stress
    • Replies: 16
    • Forum: Scientific Studies
  20. miquelangeles

    Pregnenolone acetate in treatment of mycetoma

    THE PURPOSES of this presentation are (1) to report a case of mycetoma (nocardiosis) in a child who had failed to respond to all the standard forms of therapy and who apparently has been cured by treatment with pregnenolone acetate and (2) to call attention to pregnenolone acetate as an agent...
Back
Top Bottom