sepsis

  1. haidut

    Aspirin lowers all-cause mortality

    A fascinating study, which highlights once again that there is a lot more to aspirin than "COX inhibition" (as medicine would have us believe). The study was done on ICU patients only, but I view that as an even stronger evidence in favor of aspirin, since ICU patients are in a very precarious...
  2. Mauritio

    T3 levels are a predictor of mortality from sepsis

    "The role of thyroid hormones is crucial in the response to stress and critical illness, which has been reported to be closely associated with a poor prognosis in patients admitted to the intensive care unit (ICU). This study aimed to explore the relationship between thyroid hormone and...
  3. B

    Aspirin in the context of Endotoxin Tolerance

    Summary of studies: Endotoxin tolerance (ET) is a reduced responsiveness to a LPS challenge following a first encounter with endotoxin. Chronically, this may lead to local or systemic immunosuppression. Despite ongoing low-grade tissue irritation, only a blunted immune response is mounted. On...
    • bigc
    • Thread
    • aspirin endotoxin infection inflammation lps sepsis
    • Replies: 5
    • Forum: Scientific Studies
  4. cs3000

    L-Citrulline restores immunity & T Cell mitochondria function acutely

    Citrulline looks like the best amino acid for acute use in infections to replenish immune markers A lot of viruses try to upregulate arginase in our bodies to shift more arginine into ornithine & urea - to lower protective immunity of the host . which is also seen in covid where Arginase...
    • cs3000
    • Thread
    • arginine citrulline immune function immune system immunity mitochondria function sepsis t cell proliferation t cells viral infection
    • Replies: 5
    • Forum: Scientific Studies
  5. haidut

    Progesterone and allpregnanolone are protective against COVID-19

    I think we will be seeing more studies on this topic, especially in light of the ongoing human studies administering progesterone or (gasp!) estrogen to men in the hopes of improving the course of their COVID-19 disease. The results from the estrogen trials are already - surprise, surprise -...
    • haidut
    • Thread
    • allopregnanolone covid-19 cytokine inflammation pregnancy progesterone sepsis
    • Replies: 20
    • Forum: Scientific Studies
  6. haidut

    The Tetracyclines Protect Against Sepsis Independently Of Their Antibiotics Effects

    A remarkable study, which demonstrates that not all antibiotics have been created equal. Namely, the tetracycline family of antibiotics is strikingly protective against lethality from sepsis, and that protection is completely separate from their antibiotics effects. For example, the study...
    • haidut
    • Thread
    • doxycycline flu influenza lethal prevent protect sepsis tetracycline
    • Replies: 7
    • Forum: Scientific Studies
  7. E

    Coronavirus Mutations: What Do We Know So Far?

    Skip the parts where he talks about vaccines.
    • Experienced
    • Thread
    • coronavirus covid-19 sars sepsis virus
    • Replies: 1
    • Forum: Society
  8. RWilly

    COVID-19 And Sepsis

    COVID-19 causes sepsis: "Now that more scientific data are available on COVID-19, the Global Sepsis Alliance can more definitively state that COVID-19 does indeed cause sepsis. Sepsis is “a life-threatening organ dysfunction caused by a dysregulated host response to infection.” In the case of...
  9. haidut

    Inhibiting Fatty Acid Synthesis (FAS) Dramatically Improves Sepsis Survival Rate

    Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...
    • haidut
    • Thread
    • endotoxin energy fao fas fasn fatty acid oxidation fatty acid synthase infection inhibit inhibitor randle cycle sepsis tlr tlr4
    • Replies: 6
    • Forum: Scientific Studies
  10. haidut

    Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

    It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...
    • haidut
    • Thread
    • alcoholism allopregnanolone alzheimer's antagonist cvd depression endotoxin epilepsy immune system inflammation lps ms multiple sclerosis pregnenolone ptsd schizophrenia sepsis tlr4 tnf
    • Replies: 10
    • Forum: Scientific Studies
  11. haidut

    Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix

    As many forum users know, I have been interested in the Randle Cycle (glucose/fat competition for oxidation) for quite some time. The topic of limiting fatty acid oxidation (FAO) and promoting glucose oxidation is pretty central to the metabolic theory of health. Peat has written many times on...
    • haidut
    • Thread
    • acetoacetate brain dementia endotoxin ethyl acetoacetate ethyl pyruvate fao fatty acid oxidation glucose oxidation gssg heart attack idealabs metabolism nad/nadh oxidation pdh pyruvate redox sepsis stroke
    • Replies: 602
    • Forum: IdeaLabs
  12. Amazoniac

    Gram-positive Sepsis

    - GRAM-POSITIVE SEPSIS: Mechanisms and Differences from Gram-Negative Sepsis "This article [reviews] the mechanisms by which gram-positive bacteria lead to septic shock, with regard to bacterial structure and toxicology and the host responses elicited both in animal models and in the clinical...
  13. haidut

    Serotonin Is The Likely Cause Of Septic And Anaphylactic Shock

    I am hoping that as a result of this study, mainstream medicine will finally start to take the pathogenic role of peripheral serotonin more seriously. More importantly, this study points to a rather simple and safe way of treating two of deadliest acute reactions (sepsis and allergic shock)...
    • haidut
    • Thread
    • 5-ht anaphylaxis bacteria infection platelets sepsis serotonin shock virus
    • Replies: 7
    • Forum: Scientific Studies
  14. haidut

    Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation

    Yet another great study on inosine. It shows that a HED of just 8mg/kg administered just twice daily increased the NAD/NADH ratio by a whopping factor of 15 (see attached screenshot). While inosine itself is neither a precursor to NAD (like niacinamide) nor is it an oxidizing agent, I think its...
    • haidut
    • Thread
    • inflammation inosine nad nad/nadh nadh raio redox homeostasis sepsis
    • Replies: 69
    • Forum: Scientific Studies
  15. haidut

    Baking Soda Dramatically Increases Antibiotic Effectiveness, Could Help In Sepsis

    Recently we posted some studies showing that thiamine (by itself or vitamin C) dramatically increases survival in sepsis, and lowers its severity. IV B1+Vit. C+ Cortisone Prevents Septic Induced Death Sepsis is the number one killer of hospitalized patients, so finding a way to reduce its...
    • haidut
    • Thread
    • antibacterial antibiotic baking soda bicarbonate effectiveness endotoxin infection sepsis sodium bicarbonate
    • Replies: 29
    • Forum: Scientific Studies
  16. haidut

    Aspirin As A Cure For Sepsis

    If the truly wonder-drug properties of aspirin were considered lacking by some medical authorities, now we can add curing sepsis to that list. Sepsis is the leading cause of death in hospitalized patients, regardless of age, condition, treatment, etc. It is largely considered a lost cause once...
    • haidut
    • Thread
    • aspirin caspase inflammation nsaid organ failure sepsis tlr4 treatment
    • Replies: 54
    • Forum: Scientific Studies
  17. P

    Do Not Forget To Give Thiamine To Your Septic Shock Patient!

    Do not forget to give thiamine to your septic shock patient! Thiamine was the first B vitamin to be identified and is also referred to as vitamin B1. It is a water-soluble vitamin that is an indispensable constituent of cellular metabolism (1). A lack of this vitamin can, therefore, be...
  18. haidut

    Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections

    Peat said in one of his interviews that vitamin B2, together with vitamin B1, selenium, vitamin K and CoQ10 are the most important substances for optimal mitochondrial function. I have been researching vitamin B2 and continue to be amazed at how underestimated this nutrient is both in...
    • haidut
    • Thread
    • bacteria bcaa endotoxin fad flavin mononucleotide flavine adenine dinucleotide fmn infection lps riboflavin riboflavin-5-phosphate sepsis survival tlr4 valine vitamin b2
    • Replies: 73
    • Forum: Scientific Studies
  19. haidut

    Caffeine restores cytochrome C damaged by sepsis

    Animal study and it only looked at effects of sepsis on the heart, however I do not see why the results would not apply to other organs damaged by similar methods like endotoxin (which can be considered a milder version of sepsis). Human dose would be equal to one cup of coffee or about...
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