vitamin b3

  1. haidut

    Chronic pain due to mitochondrial dysfunction, niacinamide can treat it

    As many of my readers know, there is an epidemic of chronic pain disorders in Western countries, which has subsequently led to over-prescription and (ab)use of opioid medication, which has then acted as a gateway drug and fueled a massive and deadly opioid epidemic in those countries. In order...
  2. haidut

    HUMAN STUDY: Vitamin B3 ups muscle/bone mass/strength, lowers fat, improves glucose control

    The study is epidemiological and it did not distinguish between the various forms of vitamin B3 available through the diet or supplements. However, it was well-controlled and its findings match the known biochemical effects of vitamin B3, which the study authors cite themselves as the likely...
  3. haidut

    HIV-1 Breakthrough: niacinamide as a possible treatment

    The study does not claim a cure but it is a direct corroboration of human trials with HIV-1 patients conducted back in the early 1990, as those trials used high dose niacinamide (3g daily) and found improvement in the general condition of the patients. The mechanism of actions was, again...
  4. haidut

    Niacinamide may treat Parkinson Disease (PD)

    A very interesting study, which used a relatively high dose of nicotinamide riboside (NR) to treat Parkinson Disease (PD). The dosage used was 3,000mg daily for 4 weeks and it resulted in improvement of motor and cognitive symptoms of PD, while producing no side effects. The study references...
  5. haidut

    Niacinamide may lower blood pressure in humans by raising NAD+

    The study actually used the now-banned NAD+ precursor known as nicotinamide mononucleotide (NMN), but, as I keep reminding people, multiple studies have demonstrated statistically equivalent rise in NAD+ levels from equal doses of any of the known NAD+ precursors such as niacin, niacinamide...
  6. I

    Hamsters with niacin/vitamin b3 deficiency cannibalize their young

    https://royalsocietypublishing.org/doi/10.1098/rspb.2016.2168 "This study shows that maize-based diets cause high rates of maternal infanticides in the European hamster, a farmland species on the verge of extinction in Western Europe. Vitamin B3 supplementation is shown to effectively restore...
  7. haidut

    Niacinamide may prevent neurodegeneration

    Yet another study demonstrating that maintaining high energy levels through OXPHOS is crucial for health, in this case brain health. There are many studies, going back decades, demonstrating that a drop in NAD+ levels, and thus of NAD/NADH and, consequently, of OXPHOS is a common feature of...
  8. haidut

    Vitamin B3 counteracts (cancer) cachexia, by restoring NAD+ levels

    As many of my readers know, the majority of cancer patients do not succumb from the actual tumor burden, but as a result of (usually in that order) cachexia, immunocompromise from radiation/chemotherapy, hospital-acquired infection, and/or cytokine storm after surgery for removing the tumor. Of...
  9. haidut

    A single, low dose niacinamide drops triglycerides by 75%

    Among the vitamin B3 analogs, niacin is perhaps the most famous for its ability to both raise "good" cholesterol (HDL) and also lower triglycerides. However, niacinamide, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are all effective precursors to NAD (as niacin is) and...
  10. haidut

    Low-dose niacinamide has striking anti-obesity effects

    It looks like the medical world has firmly set its sights on the bioenergetic wave/target, as the number of scientific papers focusing on niacinamide, NAD/NADH ratio and OXPHOS in general has been steadily climbing since 2010. That would be good news, despite the attempts of companies such as...
  11. haidut

    Niacin / niacinamide ratio may be a very good test for bacterial infection

    A very interesting study, which may provide a cheap, fast and easy method for testing whether a person has a bacterial or not. This is very useful in cases of respiratory diseases where a clinician has to determine if the respiratory infection is of bacterial or viral origin, in order to decide...
  12. haidut

    Niacinamide may treat lymphoma

    A very interesting study and a "synchronicity" event as well, considering the recent in-vivo experiments I conducted with a combination of vitamin B1 and vitamin B3 (niacinamide) in a mouse xenograft model of human mantle-cell lymphoma. In that experiment of mine, HED of 15mg/kg B1 and 30mg/kg...
  13. haidut

    Niacinamide + pyruvate may treat glaucoma (human study)

    Some excellent results from a human clinical trial. Namely, a combination of 3g niacinamide and 3g (calcium) pyruvate daily demonstrated significant therapeutic effect in patients with already established glaucoma. I can't access to actual study link on JAMA, but I suspect the mechanism of...
  14. haidut

    Niacinamide increases aerobic capacity, muscle endurance in humans

    There has been a steady increase in human studies with vitamin B3 analogs over the last 3-5 years. Most of that human research is sponsored by the company ChromaDex, which sells a proprietary formulation of nicotinamide riboside (NR), despite its own studies demonstrating that niacinamide /...
  15. haidut

    Glucose + vitamin B3 combo synergistic for treating mitochondrial disease

    A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating...
  16. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
  17. haidut

    Niacinamide may treat depression by improving energetic state

    A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...
  18. charlie

    Vitamin B3 (Niacinamide) Shows Promise For Glaucoma Patients In Clinical Trial

    "Results of the trial, led by Professor Jonathan Crowston and Dr. Flora Hui at the Center for Eye Research Australia, are published today in Clinical and Experimental Ophthalmology. They show "significant improvement" in the visual function of glaucoma patients who received a daily high dose of...
  19. haidut

    Niacinamide (vitamin B3) May Cure HIV (human Study)

    The title of the post sounds a bit too good to be true but this is basically what the case study claims and is also reported by the mouthpiece of Big Pharma - the Science Magazine. So, little by little the truth comes out, which is always good news. The only bad news in this case is that the...
  20. haidut

    Vitamin B3 May Treat "incurable" Muscle Disease

    Over the last 2-3 years I have seen a dramatic increase in the number of studies and popular press articles using the keywords "controversial", "paradox", "paradigm shift", "ameliorates an incurable condition X", etc. This is just a thinly veiled attempt to mask the collapse of the corrupt dogma...
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