I stumbled upon this post when looking for B6 dose direction, so thanks for sharing. I'm curious, are you saying that serotonin syndrome is irreversible? I was under the assumption that it's always reversible but it can take a very long time.I think thats why you take it at relatively low doses, no more than 10mg. It also supports dopamine function which will offset serotonin increases. It seems to help with autism, depression, Parkinson, general stress, cancer, ADHD, IBS, diabetes, and asthma. Thus suggesting its net effect is very anti-serotonin. B-6 seems to be neurotoxic in high doses (irreversible) though, probably just serotonin syndrome.