Can Thiamine Help With Anxiety/Panic - Might I Be Too High in Serotonin?

[DMF]

'Still trying to figure out my hellish episodes of unbearable anxiety/high cortisol (poor/no sleep) and wondering if it is in fact 'serotonin syndrome'?
Is there a test/blood test that would measure serotonin levels in my gut I could ask a doctor? If thiamine could help then how much,
in what form?

 

[Elie]

Someone posted here recently about receiving lots of potassium at the ER for a panic attack and there was input on that thread about interdependability of the two,
Also Haidut posted recently about B6 for depression and anxiety.
I believe both progesterone and pregnenolone oppose serotonin.
in general improving energy metabolism should help.

 

[mostlylurking]

'Still trying to figure out my hellish episodes of unbearable anxiety/high cortisol (poor/no sleep) and wondering if it is in fact 'serotonin syndrome'?
Is there a test/blood test that would measure serotonin levels in my gut I could ask a doctor? If thiamine could help then how much,
in what form?

There is a connection between thiamine deficiency and brain serotonin overload. High brain serotonin can cause high anxiety. I'm sure that B6 also plays its part.

info about thiamine and brain serotonin:

Effect of thiamine deficiency on brain serotonin turnover - PubMed

Serotonin turnover has been investigated in regional brain areas of rats made thiamine deficient by pyrithiamine (PT). Following intracisternal injection of [14C]5-hydroxytryptamine ([14C]5-HT), a marked increase in the accumulation of [14C]5-hydroxyindoleacetic acid ([14C]5-HIAA) was found in...

pubmed.ncbi.nlm.nih.gov

Alterations in serotonin parameters in brain of thiamine-deficient rats are evident prior to the appearance of neurological symptoms - PubMed

Biochemical alterations of serotoninergic parameters have been demonstrated in experimental thiamine deficiency. In addition, hypophagia and hypothermia, two physiological processes associated with changes in the serotonin [5-hydroxytryptamine (5-HT)] system, are manifest early during the...

pubmed.ncbi.nlm.nih.gov

Serotonin Syndrome and Thiamine: Is There a Connection? - Hormones Matter

A mild deficiency of thiamine is responsible for the large number of the polysymptomatic illnesses reported.

www.hormonesmatter.com

also these:

Blood-brain barrier dysfunction in thiamine-deficient, alcohol-treated rats - PubMed

Rats maintained on a thiamine-deficient diet for 38 days loss weight and showed neurological symptoms. The PA value, representing the permeability of the blood-brain barrier to 14C-sucrose, was significantly increased whether urethane or ethanol was used as anaesthetic. This increase was...

pubmed.ncbi.nlm.nih.gov

Does thiamine protect the brain from iron overload and alcohol-related dementia? - PubMed

Alcohol-related dementia (ARD) is a common and severe co-morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently...

pubmed.ncbi.nlm.nih.gov

Thiamin deficiency and brain disorders - PubMed

Thiamin plays a key role in the maintenance of brain function. Thiamin diphosphate is cofactor for several enzymes involved in glucose metabolism whereas thiamin triphosphate has distinct properties at the neuronal membrane. Thiamin metabolism in the brain is compartmented between neurons and...

pubmed.ncbi.nlm.nih.gov

for further investigation:

gut serotonin - Search Results - PubMed

gut serotonin - Search Results - PubMed

pubmed.ncbi.nlm.nih.gov

brain serotonin - Search Results - PubMed

brain serotonin - Search Results - PubMed

pubmed.ncbi.nlm.nih.gov