Sitaruîm
Member
- Joined
- Jun 14, 2020
- Messages
- 481
In Ray's article about learned helplessness, arguably his most important article, one of the main points seems to be that low cholinesterase leads to overexcitation of the nerves and to cell death. He cites articles that show that rats living in idyllic environments have high levels of cholinesterase in their brain. There are two types of cholinesterase enzymes, AChE and BChE, and caffeine is known to inhibit AChE.
How do you guys think Ray would argue in favor of coffee given his posture on cholinesterase? Does low choline consumption in the diet lower cholinergic activity in the brain, which could logically lead us to conclude that inhibiting cholinesterase would be a positive outcome? Could caffeine be harmful in the presence of high amounts of choline in the diet? I'd be particularly interested in hearing @redsun 's opinion on this, since his view seems to be that most people don't meet the daily requirement of choline.
How do you guys think Ray would argue in favor of coffee given his posture on cholinesterase? Does low choline consumption in the diet lower cholinergic activity in the brain, which could logically lead us to conclude that inhibiting cholinesterase would be a positive outcome? Could caffeine be harmful in the presence of high amounts of choline in the diet? I'd be particularly interested in hearing @redsun 's opinion on this, since his view seems to be that most people don't meet the daily requirement of choline.