dhtsupreme
Member
- Joined
- Jul 29, 2019
- Messages
- 116
Great podcast discussing how dopamine works in the brain, the pathways of the brain that enable dopaminergic transmission, what stimulates its release, and tools to optomize dopamine to prevent addiction and promote motivation and enjoyment in ones life.
What I did not know prior to this was that dopamine rises and falls below baseline after an event that stimulates dopamine. For example, if I ate a piece of chocolate I can experience a 1.5 fold increase in dopamine (varies from person to person). Sounds great except that after a period of time dopamine will actually fall below baseline for a period of time. Meaning I will be experiencing symptoms of low dopamine after experiencing this higher level.
According to him and the research he discussed, tyrosine and mucuna pruriens are part of the factors/substances that produce a temporary high and then a drop below baseline whereas caffeine and maca are indirect (producing a small rise without a dramatic drop). The study he referred to concluded tyrosine caused a sharp rise in dopamine that lasted for a half hour and began to fall. It was not tested long enough to determine if it would drop below baseline however Dr. Huberman said with everything studied on dopamine, it would be the case that it would fall below baseline due to "depletion of the readily reservible pool of dopamine vesicles". Wouldn't tyrosine fill those reserves since it increases dopamine production directly? @haidut @Hans
My question/concern is how to use substances to not have such a negative effect. I know for many lisuride has temporary effects and this may be why since it's an agonist of many dopamine receptors. It could be creating this dramatic increase for a short time then a sharp drop. For many trying to raise dopamine or believe/know they have high prolactin, this could be confusing.
Is there a way to dose lisuride/tyrosine/mucuna pruriens to not have such a dramatic rise and fall? Perhaps using much smaller doses than 500mg for tyrosine like 100mg? Maybe diluting lisuride to provide a minor increase in dopamine?
Can other indirect compounds that raise dopamine receptors like caffeine be more beneficial in the long run? (Uridine/cdp choline- D2 receptor or large doses of thiamine to upregulate D1 receptor) @Hans @haidut
View: https://www.youtube.com/watch?v=QmOF0crdyRU&t=7305s
What I did not know prior to this was that dopamine rises and falls below baseline after an event that stimulates dopamine. For example, if I ate a piece of chocolate I can experience a 1.5 fold increase in dopamine (varies from person to person). Sounds great except that after a period of time dopamine will actually fall below baseline for a period of time. Meaning I will be experiencing symptoms of low dopamine after experiencing this higher level.
According to him and the research he discussed, tyrosine and mucuna pruriens are part of the factors/substances that produce a temporary high and then a drop below baseline whereas caffeine and maca are indirect (producing a small rise without a dramatic drop). The study he referred to concluded tyrosine caused a sharp rise in dopamine that lasted for a half hour and began to fall. It was not tested long enough to determine if it would drop below baseline however Dr. Huberman said with everything studied on dopamine, it would be the case that it would fall below baseline due to "depletion of the readily reservible pool of dopamine vesicles". Wouldn't tyrosine fill those reserves since it increases dopamine production directly? @haidut @Hans
My question/concern is how to use substances to not have such a negative effect. I know for many lisuride has temporary effects and this may be why since it's an agonist of many dopamine receptors. It could be creating this dramatic increase for a short time then a sharp drop. For many trying to raise dopamine or believe/know they have high prolactin, this could be confusing.
Is there a way to dose lisuride/tyrosine/mucuna pruriens to not have such a dramatic rise and fall? Perhaps using much smaller doses than 500mg for tyrosine like 100mg? Maybe diluting lisuride to provide a minor increase in dopamine?
Can other indirect compounds that raise dopamine receptors like caffeine be more beneficial in the long run? (Uridine/cdp choline- D2 receptor or large doses of thiamine to upregulate D1 receptor) @Hans @haidut
View: https://www.youtube.com/watch?v=QmOF0crdyRU&t=7305s
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