Peroxphos
Member
- Joined
- Dec 15, 2019
- Messages
- 59
Thanks for this interesting info.I am taking 1 gram, 2Xday orally of thiamine hcl. Thiamine hcl tends to have poor success getting absorbed through the gut. It is absorbed in the duodenum (small intestine) and if you have any issues there (inflammation, SIBO, etc.) then the absorption is even worse than usual. I'm following Dr. Costantini's protocol (2 grams thiamine hcl/day based on my weight) and it has helped me a lot. 2 grams of thiamine hcl/day taken orally for 7 days = the amount received in one 100mg thiamine hcl by injection/week. See here: HDT Therapy .
I'm not sure whose "standard high dose 100-300mg daily" you are referring to. I spent about 4 months slowly increasing my dosage and experienced ups and downs in recovery until I began taking the 2 grams/day (Dr. Costantini's protocol). On that dose, my recovery stabilized.
High dose thiamine is thought to reduce cancer cells: High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate - PubMed Research has been done regarding different levels of thiamine dosage and the effect on cancer. Linking vitamin B1 with cancer cell metabolism - Cancer & Metabolism
quote: "In 2001, Comin-Anduix et al. evaluated the effect of increasing thiamine supplementation in multiples of the RDI on an Ehrlich ascites tumor-mouse model [58]. Their findings indicated a statistically significant stimulatory effect of thiamine supplementation on tumor growth compared to non-supplemented controls. Moderate doses of 12.5 to 37.5 times the RDI had the greatest stimulatory effect, peaking at approximately 250% greater tumor cell proliferation with 25 times the RDI. Interestingly, at values above 75 times the RDI, no change was found in tumor cell proliferation, and a slight decrease was found at 2,500 times the RDI. This observation suggests that there is a specific range in which thiamine supports proliferation."
You mention thiamine is poorly absorbed in the gut. Have you ever tried it topically? Such as in idealabs energin. To compare the absorption