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Higher bone mineral density in older men with diabetes and impaired fasting glucose: The Osteoporotic Fractures in Men Study
Year:
2007
Abstract Number:
0990-P
Higher bone mineral density in older men with diabetes and impaired fasting glucose: The Osteoporotic Fractures in Men Study Type 2 diabetes (DM) is relate Type 2 diabetes (DM) is related to higher bone mineral density (BMD) in older white women, perhaps due to obesity and higher fasting insulin levels, but less data exists for men or those with impaired fasting glucose (IFG). We performed a cross-sectional analyses of 2000-02 baseline data from 5,995 community dwelling, ambulatory men aged [gt]65 years from Birmingham, AL; Minneapolis, MN; Palo Alto, CA; Pittsburgh, PA; Portland, OR; and San Diego, CA in the Osteoporotic Fractures in Men (MrOS) Study. DM was defined as self-report of a diagnosis by a physician, hypoglycemic medication or fasting glucose (FG) [gt]126 mg/dl; IFG was defined as FG [gt]100 and [lt]126 mg/dl. BMD was measured by DXA (QDR 4500W, Hologic Inc) at the femoral neck and total hip and in a subset of 3207, by quantitative computerized tomography (QCT) for vertebral and femoral neck trabecular volumetric BMD (vBMD). Participants missing fasting blood draw and DM/IFG status were excluded. Of the remaining 5,556 participants (age 73.6+5.9 years; 90% white), 16% had DM and 37% had IFG. After adjustment for age, race, lean and fat mass, and fasting insulin, BMD and volumetric BMD remained 4-5% and 10-18% higher respectively in DM men and 1-2% and 5-8% higher respectively in men with IFG compared to men with normal FG for all measures (Table 1).
Table 1. BMD by DM, IFG, and normal FG status adjusted for age, race, lean mass, fat mass and fasting insulin.*p[lt]0.05 for all DM or IFG vs. normal FG
DM* IFG* Normal FG
Total hip BMD, g/cm2 0.988 0.963 0.946
Femoral neck BMD, g/cm2 0.818 0.786 0.777
Vertebral trabecular vBMD, mg/cc 0.120 0.114 0.108
Femoral neck trabecular vBMD, mg/cc 0.083 0.074 0.068
Both diabetes and IFG were positively associated with higher BMD in these older men. Men with IFG had BMD intermediate between men with DM and normal FG. Higher lean and fat mass and higher fasting insulin levels did not account for these associations. ELSA S. STROTMEYER, LYNN M. MARSHALL, ANN V. SCHWARTZ, DOUG C. BAUER, THOMAS F. LANG, ELIZABETH BARRETT-CONNOR, ERIC S. ORWOLL, JANE A. CAULEY, Pittsburgh, PA, Portland, OR, San Francisco, CA, San Diego, CA0990-P Epidemiology
Author:
ELSA S. STROTMEYER
Congress:
67th Scientific Sessions (2007)
Category:
Epidemiology
Higher bone mineral density in older men with diabetes and impaired fasting glucose: The Osteoporotic Fractures in Men Study | American Diabetes Association
Year:
2007
Abstract Number:
0990-P
Higher bone mineral density in older men with diabetes and impaired fasting glucose: The Osteoporotic Fractures in Men Study Type 2 diabetes (DM) is relate Type 2 diabetes (DM) is related to higher bone mineral density (BMD) in older white women, perhaps due to obesity and higher fasting insulin levels, but less data exists for men or those with impaired fasting glucose (IFG). We performed a cross-sectional analyses of 2000-02 baseline data from 5,995 community dwelling, ambulatory men aged [gt]65 years from Birmingham, AL; Minneapolis, MN; Palo Alto, CA; Pittsburgh, PA; Portland, OR; and San Diego, CA in the Osteoporotic Fractures in Men (MrOS) Study. DM was defined as self-report of a diagnosis by a physician, hypoglycemic medication or fasting glucose (FG) [gt]126 mg/dl; IFG was defined as FG [gt]100 and [lt]126 mg/dl. BMD was measured by DXA (QDR 4500W, Hologic Inc) at the femoral neck and total hip and in a subset of 3207, by quantitative computerized tomography (QCT) for vertebral and femoral neck trabecular volumetric BMD (vBMD). Participants missing fasting blood draw and DM/IFG status were excluded. Of the remaining 5,556 participants (age 73.6+5.9 years; 90% white), 16% had DM and 37% had IFG. After adjustment for age, race, lean and fat mass, and fasting insulin, BMD and volumetric BMD remained 4-5% and 10-18% higher respectively in DM men and 1-2% and 5-8% higher respectively in men with IFG compared to men with normal FG for all measures (Table 1).
Table 1. BMD by DM, IFG, and normal FG status adjusted for age, race, lean mass, fat mass and fasting insulin.*p[lt]0.05 for all DM or IFG vs. normal FG
DM* IFG* Normal FG
Total hip BMD, g/cm2 0.988 0.963 0.946
Femoral neck BMD, g/cm2 0.818 0.786 0.777
Vertebral trabecular vBMD, mg/cc 0.120 0.114 0.108
Femoral neck trabecular vBMD, mg/cc 0.083 0.074 0.068
Both diabetes and IFG were positively associated with higher BMD in these older men. Men with IFG had BMD intermediate between men with DM and normal FG. Higher lean and fat mass and higher fasting insulin levels did not account for these associations. ELSA S. STROTMEYER, LYNN M. MARSHALL, ANN V. SCHWARTZ, DOUG C. BAUER, THOMAS F. LANG, ELIZABETH BARRETT-CONNOR, ERIC S. ORWOLL, JANE A. CAULEY, Pittsburgh, PA, Portland, OR, San Francisco, CA, San Diego, CA0990-P Epidemiology
Author:
ELSA S. STROTMEYER
Congress:
67th Scientific Sessions (2007)
Category:
Epidemiology
Higher bone mineral density in older men with diabetes and impaired fasting glucose: The Osteoporotic Fractures in Men Study | American Diabetes Association
