Texon
Member
- Joined
- Nov 28, 2016
- Messages
- 672
Great finds!This study done for the US Army Medical Research and Material Command Fort Detrick Maryland https://apps.dtic.mil/dtic/tr/fullt...NqTJR28NipeY3L7DZj0HKCqpD0f92HBGr9YzIr97UByR4 shows how well Fenbendazole works on Hormone-Refractory Metastatic Prostate Cancer.
"From this screening sequence, we finally identified five candidate drugs: clofazimine, fenbendazole, fluspirilene, niclosamide and suloctidil, that selectively exert cytotoxic effects on all metastatic prostate cancer cell lines tested but not on normal rat epithelial cells."
"Fenbendazole, in particular, demonstrated greater survival-promoting effects among other
agents. Fenbendazole was also cytotoxic against paclitaxel-resistant prostate cancer, one of the
major challenges in the clinic."
Per Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
"FZ demonstrates moderate affinity for mammalian tubulin and exerts cytotoxicity to human cancer cells at micromolar concentrations. Simultaneously, it caused mitochondrial translocation of p53 and effectively inhibited glucose uptake"
This is how Fenbendazole does it https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436308/pdf/zbc30625.pdf
Just started the 4th application.