Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications.
Tardivo JP1, Del Giglio A1, de Oliveira CS2, Gabrielli DS2, Junqueira HC2, Tada DB2, Severino D2, de Fátima Turchiello R2, Baptista MS2.
Abstract
Methylene blue (MB) is a molecule that has been playing important roles in microbiology and pharmacology for some time. It has been widely used to stain living organisms, to treat methemoglobinemia, and lately it has been considered as a drug for photodynamic therapy (PDT). In this review, we start from the fundamental photophysical, photochemical and photobiological characteristics of this molecule and evolved to show in vitro and in vivo applications related to PDT. The clinical cases shown include treatments of basal cell carcinoma, Kaposi's Sarcoma, melanoma, virus and fungal infections. We concluded that used together with a recently developed continuous light source (RL50(®)), MB has the potential to treat a variety of cancerous and non-cancerous diseases, with low toxicity and no side effects.
Here the link to the full study:
http://libgen.org/scimag/get.php?doi=10 ... %2900097-9
A very huge THANK YOU to Ray Peat who kindly sent me this study.
Tardivo JP1, Del Giglio A1, de Oliveira CS2, Gabrielli DS2, Junqueira HC2, Tada DB2, Severino D2, de Fátima Turchiello R2, Baptista MS2.
Abstract
Methylene blue (MB) is a molecule that has been playing important roles in microbiology and pharmacology for some time. It has been widely used to stain living organisms, to treat methemoglobinemia, and lately it has been considered as a drug for photodynamic therapy (PDT). In this review, we start from the fundamental photophysical, photochemical and photobiological characteristics of this molecule and evolved to show in vitro and in vivo applications related to PDT. The clinical cases shown include treatments of basal cell carcinoma, Kaposi's Sarcoma, melanoma, virus and fungal infections. We concluded that used together with a recently developed continuous light source (RL50(®)), MB has the potential to treat a variety of cancerous and non-cancerous diseases, with low toxicity and no side effects.
Here the link to the full study:
http://libgen.org/scimag/get.php?doi=10 ... %2900097-9
A very huge THANK YOU to Ray Peat who kindly sent me this study.