Among the several SSRIs I've tried, Prozac was the most effective. I took a low dose for two periods of several months, and strangely the effects were most noticeable when I stopped. The effect lasted for several weeks. I felt euphoric, a sense of clarity and confidence that I can't compare to any other time in my life. Both resulted in the start of a new relationship, so I'm not sure if this could partially be explained by horomones/love, but then the classic chicken vs. egg argument is valid too. It's just odd because my PTSD prevented the formation of any relationship, let alone romantic relationships, over the last decade or so. Can anybody offer an explanation for this phenomenon?
Prozac is an 5-HT2C antagonist, similar to cyproheptadine. Most 5-Ht2C antagonists stimulate allopreganolone production and are known potent antidepressants. Unfortunately, the serotonergic effects of Prozac really accumulate over time and fibrsis and psychosis set in with chronic use.
Why does Prozac work?