Makrosky
Member
- Joined
- Oct 5, 2014
- Messages
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I don't know enough body biochemistry to have a conclusion but it's hitting the news this week. They claim that palmitic acid (saturated fat) is responsible for cancer metastasis. Rodent study btw and only oral cancer.
@paymanz @haidut
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature20791.html
Targeting metastasis-initiating cells through the fatty acid receptor CD36
Nature
(2016)
doi:10.1038/nature20791
Received
27 January 2027
Accepted
16 November 2016
Published online
07 December 2016
Abstract
The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44bright cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis. Palmitic acid or a high-fat diet specifically boosts the metastatic potential of CD36+ metastasis-initiating cells in a CD36-dependent manner. The use of neutralizing antibodies to block CD36 causes almost complete inhibition of metastasis in immunodeficient or immunocompetent orthotopic mouse models of human oral cancer, with no side effects. Clinically, the presence of CD36+ metastasis-initiating cells correlates with a poor prognosis for numerous types of carcinomas, and inhibition of CD36 also impairs metastasis, at least in human melanoma- and breast cancer-derived tumours. Together, our results indicate that metastasis-initiating cells particularly rely on dietary lipids to promote metastasis.
@paymanz @haidut
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature20791.html
Targeting metastasis-initiating cells through the fatty acid receptor CD36
Nature
(2016)
doi:10.1038/nature20791
Received
27 January 2027
Accepted
16 November 2016
Published online
07 December 2016
Abstract
The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44bright cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis. Palmitic acid or a high-fat diet specifically boosts the metastatic potential of CD36+ metastasis-initiating cells in a CD36-dependent manner. The use of neutralizing antibodies to block CD36 causes almost complete inhibition of metastasis in immunodeficient or immunocompetent orthotopic mouse models of human oral cancer, with no side effects. Clinically, the presence of CD36+ metastasis-initiating cells correlates with a poor prognosis for numerous types of carcinomas, and inhibition of CD36 also impairs metastasis, at least in human melanoma- and breast cancer-derived tumours. Together, our results indicate that metastasis-initiating cells particularly rely on dietary lipids to promote metastasis.
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