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- Oct 30, 2015
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Interestingly the carvacrol content was very small (up to 0.1%) and didn't see a total amount t specified. Compare with high double digit percentage amounts of oregano oll supplements. I will look to see if there are any similar human studies...There’s some evidence carcavol (in oregano oil) reduces resistant bacteria. I’m not sure if it depends on dosage.
“In this study, CR treatment did not reduce the bacterial diversity in the mouse gut. To date, a majority of the antimicrobial compounds, especially antibiotics, have significantly altered the microbial diversity, and cause dysbiosis by changing the abundance of bacterial communities (Semenyuk et al., 2015). Moreover, CR treatment significantly increased the abundance of beneficial bacterial populations such as Firmicutes, specifically the members of Lactobacillaceae and Lachnospiraceae. In addition, CR treatment alone did not increase the abundance of detrimental bacterial populations compared to untreated control animals. Strikingly, CR reduced antibiotic-induced increases in the abundance of unfavorable bacterial populations such as Proteobacteria, specifically pathogenic gamma proteobacteria, including Enterobacteriaceae and other bacterial populations such as Verrucobacteria (Figure (Figure5).5). Surprisingly, this beneficial shift brought about by CR treatment in the gut microbiome of antibiotic-treated and C. difficile infected animals is very much similar to that of human patients who have undergone fecal microbiome transplantation (Weingarden et al., 2014), which is documented as one of the most effective strategies against severe C. difficile infection (Schenck et al., 2015; Ofosu, 2016). These results suggest that reduced or delayed clinical infection rate and less severe clinical presentation of CR-treated animals could attributed in part to the beneficial shift in the gut microbiome.
To conclude, our results suggest CR supplementation to be protective against C. difficile infection in mice. Carvacrol supplementation significantly reduced the incidence of diarrhea and mitigated the severity of C. difficile induced clinical symptoms, inducing a favorable shift in the composition of the gut microbiota without detrimentally affecting the gut microbiome diversity in mice.”