Just came across this CBC article in which researchers at McMaster are sounding quite like Peat.
http://www.cbc.ca/news/canada/hamilton/ ... -1.2862231
http://www.cbc.ca/news/canada/hamilton/ ... -1.2862231
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jaa said:Just came across this CBC article in which researchers at McMaster are sounding quite like Peat.
http://www.cbc.ca/news/canada/hamilton/ ... -1.2862231
loess said:haidut, they used that experimental drug that you linked to (LP-533401), apparently originally developed and tested in humans as a treatment for irritable bowel syndrome, but more recently aimed at inhibiting gut-derived serotonin synthesis for the purpose of treating osteoporosis.
Full text of the study is attached to this post.
I'm afraid we don't get the vitamin D dose figured out. I am not going to repeat myself, but vitamin D suppletion does not indiscriminately mean increased VDR activity.So, it seems that the best options right now are vitamin D (if we figure out the dosage)
Kasper said:Just one thought:
inhibiting gut serotonin --> increase brown fat cells
the iceman --> has much increased brown fat cells
cold showers --> increase brown fat cells
Could it be that cold showers actually lower gut serotonin. I understand, cold showers can get someone in a stress state, but if you go very slowly, from warm to cold, and are in general a good health, my experience is that it feels not stressy, but it feels very good. The highest body temperature that I've ever measured (37 degrees) was right after I did a cold shower. Like 2 mins, after a cold shower.
The important thing to note is that they found that inhibiting peripheral serotonin is the key to restoring metabolism. They claim that serotonin reduction in the brain has no effect or at least they think it would have no effect.
Here is the actual study, so if somebody has access to it and can check what chemical they used to inhibit TPH-1 that would be great.
http://www.nature.com/nm/journal/vaop/n ... .3766.html