4 sentences that explain a lot

[Blossom]

From Resveratrol, rate of living, CO2 and aging September 2009
Ray wrote

One factor involved in the increased production of TSH in hypothyroidism is that the low metabolic rate allows estrogen to accumulate, leading to increased serotonin production. Serotonin stimulates both TSH and prolactin. Serotonin and prolactin both happen to cause bone loss. They increase nitric oxide, which inhibits mitochondrial respiration.