A new theory on hair loss - why Hair is never truly dead and bald men can regrow their hair back naturally

[CastorTroy]

@CastorTroy So testosterone and any derivatives when applied to the genitals will only promote augmentation in that area and also enlargement? I think there are many 5AR receptors, but in the same way I could cause inhibition

It could accelerate augmentation yes, but the outcome may vary depending on the amount of active reaching the tissue, and individual factors like 5AR density which can greatly vary depending on genetics.

 

[jondoeuk]

A new topical drug is in development. It is a potent mitochondrial pyruvate carrier inhibitor that acts on the cellular metabolic pathway to upregulate lactate dehydrogenase, which stem cells are particularly sensitive to, resulting in the activation of dormant hair follicle stem cells, restoring the regenerative capacity of the follicle and triggering new hair growth.

A Phase 1 clinical trial concluded in Jan, which demonstrated that it was safe and well-tolerated, with the target pharmacokinetic profile achieved. Additionally, the trial demonstrated proof-of-mechanism and target engagement in patients with androgenetic alopecia. There was a statistically significant increase in the Ki67 signal compared to baseline after just seven days of topical (0.05%) treatment. Evidence of newly emerging hair germs – the hallmark of the telogen to anagen transition - was also observed.

A Phase 2 trial will open soon Safety, Pharmacokinetics and Efficacy of PP405 in Adults With AGA - Full Text View - ClinicalTrials.gov