Acetyl-L-carnitine to maximize testosterone and erections

[Hans]

Acetyl-L-carnitine to maximize testosterone and erections » TESTONATION

Acetyl-L-carnitine might have a positive influence on your androgens. Carnitine is a naturally found compound in the body that’s involved in energy metabolism and removing products of metabolism from cells. In the body, 75% of carnitine is ingested from the diet, and 25% is synthesized...

men-elite.com

Before some of you lose your mind about carnitine enhancing fat oxidation, carnitine actually promotes proper glucose oxidation. I discuss this in the article.

Also, an interesting snippet you might find interesting is the fact that carnitine-L-tartrate likely doesn't boost androgen receptors.

 

[cs3000]

nearer a typical heq dose shows red blood cell h2o2 protection (scavenger?) in vivo http://mmsl.cz/pdfs/mms/2022/04/07.pdf

https://clinicalnutritionespen.com/article/S2405-4577(16)30241-8/pdf

https://pubmed.ncbi.nlm.nih.gov/15842073/

high dose restores brain glutathione in vivo Carnitine as a free radical scavenger in aging

~1g heq liver & mitochondria protection in vivo copper overload https://onlinelibrary.wiley.com/doi/10.1002/ijc.20636


Some problems tho like u mentioned in your article a couple years back,
it inhibits thyroid
the ramp up in oxidation can cause more electron leak / h2o2 (but i guess carnitine antioxidant function is to counter this)
https://men-elite.com/2020/03/03/ca...-view-and-why-it-can-actually-be-bad-for-you/

it inhibits t3 uptake into cell nucleus
https://www.liebertpub.com/doi/10.1089/thy.2000.10.1043
Effects of carnitine on thyroid hormone action - PubMed
Usefulness of l-Carnitine, A Naturally Occurring Peripheral Antagonist of Thyroid Hormone Action, in Iatrogenic Hyperthyroidism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
hyperthyroidsm shows low carnitine levels in tissue

so you cant get around the t3 impairment by replacing with exogenous t3, will also have impaired uptake in the cell
think it competes for transport using MCT9

also dont like how it increases vivid overactive dreaming. but idk if that's only the acetyl version or not
https://www.e-agmr.org/upload/pdf/Kgs018-03-06.pdf
by inducing glutamate release in sublaterodorsal nucleus. and increasing acetylcholine.

 

[Snarf]

I’ve tried injectable l carnitine. I heard that it could up regulate androgen receptors so I gave it a try. Didnt get any positive benefits from it though, it just made me very hot and sweaty when lifting. I cant remember the reason why, but I remember thinking that it wasnt doing my thyroid any good so I stopped taking it.

That said, I was under dosing it. The stuff I had was only 200mg per ml, and pinning 1 ml into my delt every day was bad enough, I wasnt prepared to pin 3ml.

 

[bobbity]

Acetyl-L-carnitine to maximize testosterone and erections » TESTONATION

Acetyl-L-carnitine might have a positive influence on your androgens. Carnitine is a naturally found compound in the body that’s involved in energy metabolism and removing products of metabolism from cells. In the body, 75% of carnitine is ingested from the diet, and 25% is synthesized...

men-elite.com

Before some of you lose your mind about carnitine enhancing fat oxidation, carnitine actually promotes proper glucose oxidation. I discuss this in the article.

Also, an interesting snippet you might find interesting is the fact that carnitine-L-tartrate likely doesn't boost androgen receptors.

I really think you're abusing this forum. Clickbaiting to external links...if you were really interested in engaging you would simply do as haidut does and post content.

 

[Hans]

nearer a typical heq dose shows red blood cell h2o2 protection (scavenger?) in vivo http://mmsl.cz/pdfs/mms/2022/04/07.pdf

https://clinicalnutritionespen.com/article/S2405-4577(16)30241-8/pdf

https://pubmed.ncbi.nlm.nih.gov/15842073/

high dose restores brain glutathione in vivo Carnitine as a free radical scavenger in aging

~1g heq liver & mitochondria protection in vivo copper overload https://onlinelibrary.wiley.com/doi/10.1002/ijc.20636


Some problems tho like u mentioned in your article a couple years back,
it inhibits thyroid
the ramp up in oxidation can cause more electron leak / h2o2 (but i guess carnitine antioxidant function is to counter this)
https://men-elite.com/2020/03/03/ca...-view-and-why-it-can-actually-be-bad-for-you/

it inhibits t3 uptake into cell nucleus
https://www.liebertpub.com/doi/10.1089/thy.2000.10.1043
Effects of carnitine on thyroid hormone action - PubMed
Usefulness of l-Carnitine, A Naturally Occurring Peripheral Antagonist of Thyroid Hormone Action, in Iatrogenic Hyperthyroidism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
hyperthyroidsm shows low carnitine levels in tissue

so you cant get around the t3 impairment by replacing with exogenous t3, will also have impaired uptake in the cell
think it competes for transport using MCT9

also dont like how it increases vivid overactive dreaming. but idk if that's only the acetyl version or not
https://www.e-agmr.org/upload/pdf/Kgs018-03-06.pdf
by inducing glutamate release in sublaterodorsal nucleus. and increasing acetylcholine.

I wonder if the decrease in T3 uptake is to prevent tissue hyperthyroidism, since carnitine promotes the oxidation of both glucose and fat.
I haven't read of anyone who became hypothyroid while using carnitine. Rather people become hot and sweaty as @Snarf experienced.

 

[liam183]

I tried L-carnitine tartrate and all it seemed to do was make me hungry all the time

 

[Steed]

Why post topics on the Ray Peat forum that goes directly against the teachings of Ray Peat?

 

[Hans]

Why post topics on the Ray Peat forum that goes directly against the teachings of Ray Peat?

Otherwise, it's a religion/cult that no one questions, even if there are holes.

 

[John mcclain]

Why post topics on the Ray Peat forum that goes directly against the teachings of Ray Peat?

He constantly promotes absolute crap...whilst stepping around the actual substance he wants to actually increase...whilst he poses with his shirt off..rather strange but hey his clients seem happy to pay him when it seems to me he knows an awful lot about nothing.

 

[LukeL]

Why post topics on the Ray Peat forum that goes directly against the teachings of Ray

Otherwise, it's a religion/cult that no one questions, even if there are holes.

100% - I never understand why you wouldn’t celebrate alternative thinking here (even if you don’t agree with it)

 

[76er]

I really think you're abusing this forum. Clickbaiting to external links...if you were really interested in engaging you would simply do as haidut does and post content.

There's nothing wrong with this practice as an individual has the right to 'own' their content by having it in place that they control.

I'd agree that there would probably be more engagement if the article(s) in their entirely (but condensed for easy scanning and reading) were crossposted directly to a thread.

 

[iMusclebuild]

He constantly promotes absolute crap...whilst stepping around the actual substance he wants to actually increase...whilst he poses with his shirt off..rather strange but hey his clients seem happy to pay him when it seems to me he knows an awful lot about nothing.

So, are you saying other POV's shouldn't be shared here? I'm not sure what his shirtless pic has to do with anything.

 

[theoogabear]

can we bring the topic back? i have diagnosed fatty liver, so supplements like this and choline are of great interest to me.

@Hans , in your opinion, what's the best carnitine supplement? seems like they all have different effects, no? i just bought acteyl-carnitine based on the research you posted. is there anything to be weary of? like carnitine depleting nutrients/metals, etc?

 

[Roni123@]

@Hans for bad health you recomend methionine, cisteíne and tryptophan? its not reduce energy production and testoreone?

 

[Jremy25]

Would injectable L carnitine used in blast cycles with high dose transdermal DHT force the body to upregualte androgen receptor expression? Theoretically speaking of course.

I’m using transdermal DHT at the moment and have been considering adding injectable L carnitine to supercharge the effects and hopefully attain a long term benefit to androgen receptor sensitivity.

 

[Hans]

can we bring the topic back? i have diagnosed fatty liver, so supplements like this and choline are of great interest to me.

@Hans , in your opinion, what's the best carnitine supplement? seems like they all have different effects, no? i just bought acteyl-carnitine based on the research you posted. is there anything to be weary of? like carnitine depleting nutrients/metals, etc?

Good old ALCAR should be fine.

"carnitine inhibits β-oxidation, improves mitochondrial dysfunction, and reduces insulin resistance to ameliorate NAFLD. L-carnitine may have therapeutic role in liver diseases including non-alcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, alcoholic fatty liver disease, and viral hepatitis." Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update

 

[Hans]

@Hans for bad health you recomend methionine, cisteíne and tryptophan? its not reduce energy production and testoreone?

I don't recommend those. I recommend eating foods that you do good on and high protein foods often help make people feel better.

 

[Hans]

Would injectable L carnitine used in blast cycles with high dose transdermal DHT force the body to upregualte androgen receptor expression? Theoretically speaking of course.

I’m using transdermal DHT at the moment and have been considering adding injectable L carnitine to supercharge the effects and hopefully attain a long term benefit to androgen receptor sensitivity.

Maybe, but there is only one study on that effect. I've tried injectable carnitine before. It burns a lot and I can't say I noticed much.

 

[Jremy25]

Maybe, but there is only one study on that effect. I've tried injectable carnitine before. It burns a lot and I can't say I noticed much.

Did you use injectable carnitine on its own or with androgens?

 

[Badger]

Maybe, but there is only one study on that effect. I've tried injectable carnitine before. It burns a lot and I can't say I noticed much.

I've found 3 items pertinent to or about injectable carnitine:

Differential effects of oral and intravenous l-carnitine on serum lipids: is the microbiota the answer?

Differential effects of oral and intravenous l-carnitine on serum lipids: is the microbiota the answer?

www.ncbi.nlm.nih.gov

Effects of switching from oral administration to intravenous injection of l-carnitine on lipid metabolism in hemodialysis patients

Effects of switching from oral administration to intravenous injection of l-carnitine on lipid metabolism in hemodialysis patients

Carnitine deficiency may contribute to cardiovascular disease (CVD) in patients with hemodialysis (HD). Dyslipidemia plays a role in CVD and its prevalence is also high in HD patients. We examined here the effects of switching from oral administration ...

www.ncbi.nlm.nih.gov

The Clinical Study of the Efficacy and Safety of L-Carnitine Injection in Treatment of Heart Failure

The Clinical Study of the Efficacy and Safety of L-Carnitine Injection in Treatment of Heart Failure - Full Text View - ClinicalTrials.gov

The Clinical Study of the Efficacy and Safety of L-Carnitine Injection in Treatment of Heart Failure - Full Text View.

classic.clinicaltrials.gov