@andrewlee224
Also, consider the influence of dietary fat on endotoxin bloodstream distribution:
Probably maximum mitigation and reduction of endotoxin production by bacteria. Implying a clean gut with regular/fast transit time and good oral hygeine. TLR4 blockers like cyproheptadine can potentially be of use, but dietary changes should always come first before considering supplements.@Mufasa how did you make it go away? Thank you!
Also, consider the influence of dietary fat on endotoxin bloodstream distribution:
...represents the points that I want to make, which I state up front:
(1) Eating Dietary Fat increases the observed gut-derived endotoxin in the bloodstream. The effect usually starts 2-4 hours after eating fat, and lasts for up to 12 hours in healthy subjects [see paper (a)]
(2) The more double bonds in a fat, the LESS endotoxin gets into the serum. A PUFA like DHA will cause less endotoxin to be transferred into the bloodstream, as compared to a Saturated Fat like Coconut Oil. [paper (a)]
(3) In Diabetics, this effect is much more pronounced -- 60% greater levels of circulating endotoxin in serum after eating fat, as compared to "healthy" subjects [paper (b)]
(4) Endotoxin is transported by chylomicrons -- the lipoprotein "Fat Carriers" which transport dietary fat from the GI tract, and deliver them to tissues.
This DOES NOT involve any compromise to intestinal barrier function [paper (c)], but as a result, it is a completely inevitable side effect of consuming fat. ie: if you eat fat, existing endotoxin in the gut can and will be transported into the bloodstream within chylomicrons
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