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This was an interesting study that I thought was worth sharing.
Many detrimental substances/compounds/neurotransmitters/hormones, are able to increase neurogenesis and are supposed to be beneficial. This study made me think of what Peat said about certain SSRI drugs increasing allopregnanolone. For example, Prozac can increase allopregnanolone and that's one of the reasons why it helps against depression. So why is a harmful chemical increasing a beneficial compound such as allopregnanolone. Peat said that anything that damages the brain can increase allopregnanolone.
This study showed that alcohol reduced B1 in the brain, caused oxidative stress and stimulated neurogenesis.
"Alcohol altered the levels of several neurotransmitters and neurotrophic factors in the brain including gamma-Aminobutyric acid (GABA), corticotropin-releasing factor, cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor. Alcohol increased the expression of neuroinflammation markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor 2 (CCR2). Alcohol also induced cleaved caspase-3 and glial fibrillary acidic protein, indicative of neurodegeneration and gliosis. In addition, alcohol inhibited the expression of thiamine transporters in the brain and reduced thiamine levels in the blood. Alcohol also caused oxidative stress and endoplasmic reticulum (ER) stress, and stimulated neurogenesis."
So just because something stimulates mitochondrial biogenesis or neurogenesis, doesn't mean that it's a good substance to use.
Many detrimental substances/compounds/neurotransmitters/hormones, are able to increase neurogenesis and are supposed to be beneficial. This study made me think of what Peat said about certain SSRI drugs increasing allopregnanolone. For example, Prozac can increase allopregnanolone and that's one of the reasons why it helps against depression. So why is a harmful chemical increasing a beneficial compound such as allopregnanolone. Peat said that anything that damages the brain can increase allopregnanolone.
This study showed that alcohol reduced B1 in the brain, caused oxidative stress and stimulated neurogenesis.
Chronic Voluntary Alcohol Drinking Causes Anxiety-like Behavior, Thiamine Deficiency, and Brain Damage of Female Crossed High Alcohol Preferring Mice
The central nervous system is vulnerable to chronic alcohol abuse, and alcohol dependence is a chronically relapsing disorder which causes a variety of physical and mental disorders. Appropriate animal models are important for investigating the underlying ...
www.ncbi.nlm.nih.gov
So just because something stimulates mitochondrial biogenesis or neurogenesis, doesn't mean that it's a good substance to use.