Hey guys,
I'm interested in taking B6 for reducing prolactin, and also because I used to believe it'd reduce serotonin by shunting tryptophan into niacin (this is a claim made by Peat that has floated around the forums a few times).
I have since found studies that found B6 to increase, rather than decrease, serotonin.
1.
Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography
"The effect of pyridoxine on aromatic amino acid decarboxylase activity supported a regulatory role of pyridoxine on the synthesis of neurotransmitter [serotonin] in vivo, and may be of importance in diseases with deficiencies in neurotransmitter function."
2.
The Effect of Pyridoxine Hydrochloride on Blood Serotonin and Pyridoxal Phosphate Contents in Hyperactive Children
"Oral doses of pyridoxine resulted in an appreciable increase in the serotonin content and a very large increase in the PLP content of blood in these hyperactive patients."
3.
Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain
"Results suggest that pyridoxine plays a role in tryptophan metabolism, increasing production of 5-HTP."
I find these findings to be especially worrying, because B6 is quite commonly used to reduce prolactin.
Does anyone have anything to share about this?
I'm interested in taking B6 for reducing prolactin, and also because I used to believe it'd reduce serotonin by shunting tryptophan into niacin (this is a claim made by Peat that has floated around the forums a few times).
I have since found studies that found B6 to increase, rather than decrease, serotonin.
1.
Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography
"The effect of pyridoxine on aromatic amino acid decarboxylase activity supported a regulatory role of pyridoxine on the synthesis of neurotransmitter [serotonin] in vivo, and may be of importance in diseases with deficiencies in neurotransmitter function."
2.
The Effect of Pyridoxine Hydrochloride on Blood Serotonin and Pyridoxal Phosphate Contents in Hyperactive Children
"Oral doses of pyridoxine resulted in an appreciable increase in the serotonin content and a very large increase in the PLP content of blood in these hyperactive patients."
3.
Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain
"Results suggest that pyridoxine plays a role in tryptophan metabolism, increasing production of 5-HTP."
I find these findings to be especially worrying, because B6 is quite commonly used to reduce prolactin.
Does anyone have anything to share about this?