md_a
Member
- Joined
- Aug 31, 2015
- Messages
- 468
Discussion & conclusion
Based on the literature and clinical observation of mysterious clots reported in the COVID-19 patients, expression of ACE2 in the endothelium of blood vessels, blood clotting pathways, interaction of the SARS-CoV-2 spike protein with host ACE2, the pathogenesis of SARS-CoV-2, and the role of ACE2 in RAS, we can hypothesize and end with the conclusion that the mysterious clots reported in the COVID-19 patients may be due to the binding of the spike protein of SARS-CoV-2 with the ACE2 receptor expressed in the endothelial cells of blood vessels which may cause, vasoconstriction and activation of the intrinsic pathway of coagulation and eventually results in the formation of blood clots.Blood clots in COVID-19 patients: Simplifying the curious mystery
The universal phenomenon of blood clotting is well known to be protective in external cellular/ tissue injury. However, the emergence of unusual thrombotic presentations in COVID-19 patients is the real concern. Interaction of the spike glycoprotein with ...
www.ncbi.nlm.nih.gov