Been megadosing B1 lately and it hit me, would having a lot of thiamine lead to more ROS overproduction due to a surplus of NADPH oxidase being produced from thiamine enabling a lot of NADPH to be produced? Or does the body simply know enough is enough?
Secondly, since thiamine is also a carbonic anydrase inhibitor, what is to keep it from causing increased urination by its action of causing excretion of bicarbonate in the kidneys?
Secondly, since thiamine is also a carbonic anydrase inhibitor, what is to keep it from causing increased urination by its action of causing excretion of bicarbonate in the kidneys?