andrewlee224
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- Oct 4, 2020
- Messages
- 79
Chemically induced reprogramming to reverse cellular aging | Aging
Aging | doi:10.18632/aging.204896. Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan...
www.aging-us.com
From how I understand it - Yamanaka factors can be used to reprogram cells back into stem cells. Initially during the process, before the cells fully turn into stem cells, they appear to rejuvenate.
Yamanaka factors can be produced by tweaking gene expression, however in this case, they were induced by chemical compounds instead (so no need to attempt changing gene expression directly). Let me know if I misrepresented something - I'm not an expert on this.
It seems that cell reprogramming is quite a different approach to longevity than Peat's principles - what are your thoughts on it? Instead of improving metabolism leading to fixing cellular damage, here the cells turn back in time almost "for free". However, according to some studies these changes may lead to cancer. Perhaps it's an effect of trying to induce rejuvenation without supplying enough energy. Maybe a fusion of both approaches (cellular reprogramming and optimising metabolism / energy production) would yield best results?
