Candeias
Member
- Joined
- Apr 29, 2018
- Messages
- 220
Does anyone have experience with the antipsychotic Chlorpromazine? It looks like it could be used for serotonin syndrome and that piqued my curiosity.
Serotonin Syndrome
"(...)If a patient still remains agitated after the use of benzodiazepines and stabilization of vital signs, serotonin antagonists can be administered; 5HT-2A receptor antagonists seem to be the most effective. Animal studies have shown that because of their 5HT-2A receptor antagonism, both cyproheptadine and chlorpromazine in high doses can be used to prevent hyperthermia and lethality in serotonin syndrome. Cyproheptadine is the more potent 5HT-2A receptor antagonist and therefore may be more effective than chlorpromazine."
Serotonin Syndrome
"(...)If a patient still remains agitated after the use of benzodiazepines and stabilization of vital signs, serotonin antagonists can be administered; 5HT-2A receptor antagonists seem to be the most effective. Animal studies have shown that because of their 5HT-2A receptor antagonism, both cyproheptadine and chlorpromazine in high doses can be used to prevent hyperthermia and lethality in serotonin syndrome. Cyproheptadine is the more potent 5HT-2A receptor antagonist and therefore may be more effective than chlorpromazine."
